【作者】 陈汐敏；

【导师】 冯振卿；

【作者基本信息】 南京医科大学 ， 病理学， 2006， 硕士

【摘要】 滴虫性生殖道炎是一种常见的性传播疾病，甲硝唑是临床治疗滴虫性生殖道炎的常用药物，由于其存在口服胃肠道反应重，副作用大；孕妇不能口服用药；用药疗程较长；病人用药依从性差等缺点，因此经阴道粘膜局部给药，延长药物作用时间，减少药量进而减轻药物副作用，成为抗滴虫药物研发的热点问题。 载药纳米微粒是纳米技术与现代医药学结合的产物，是一种新型的药物输送载体。由于其具有小尺寸效应、量子效应、表面和界面效应以及纳米粒的协同效应，使物质的很多性能发生变化，可产生许多普通药物不具备的功能。目前认为纳米微粒在药物输送方面具有许多优越性：(1)可缓释药物，从而延长药物作用时间；(2)可开辟一些新的给药途径；(3)可在保证药物作用的前提下，减少给药剂量，从而减轻或减免毒副反应；(4)可达到靶向输送的目的。载药纳米微粒的这些特点都是其他输送体系所无法比拟的。 目前许多研究表明相对于普通药物，纳米药物确实具有其独特的优势，提示可应用纳米制药技术对目前现有的抗滴虫药物——甲硝唑进行改进。本文制备了两种甲硝唑纳米粒子并对其物理和化学性质进行表征；通过体外实验观察对滴虫的抑杀作用，体内实验观察对小鼠滴虫性生殖道炎症的治疗情况，以评价甲硝唑纳米粒子对滴虫性生殖道炎症的治疗效果。更多还原

【Abstract】 Trichomonas vaginalis is one of sexually transmitted diseases. Metronidazole is the common treatment of choice for genitourinary infections caused by Trichomonas vaginalis in clinical. But it has many serious side effects on gastrointestinal tract, and should not be used during pregnancy, particularly during the first 3 weeks of gestation. What’s more, the course of treatment is as long as 7 to 10 days without interval, which results in poor compliance of patients. As a result, intravaginal controlled drug administration, delaying drug effect, deducting drug doses and reducing side effect, become the hot topic in anti-trichomonad drug development.Drug-loaded nanoparticles are developed with nanotechnology and modern medicine science. Because nanoparticles possess quantum size, grand quantum size, surface effect and cooperation effect, hey exhibit many characteristics which isn’t existed in normal drugs, such as great specific surface area, high surface activity, strong absorbing ability, high catalytic efficiency, low toxicity, and not easily degradable. The development of biology and medicine will be speeded up with the progress of nanotechnology and the understanding of nanoparticles.更多还原