【作者】 顾伟；

【导师】 左保齐；

【作者基本信息】 苏州大学 ， 纺织工程， 2006， 硕士

【摘要】 生物可降解材料具有良好的生物相容性和生物安全性,聚合物和降解产物对机体毒副作用小,能满足多种生物医学功能需要,当今生物可降解材料在医学上的热点已经开始从缝合、固定等方面向组织工程支架材料方面发展。丝素(SF)是一种天然高分子材料,具有良好的生物亲和性,对机体无毒性,无致敏和刺激作用,除已用于外科手术缝合线、食品添加剂和化妆品外,近年诸多研究者已指出了将它用于人工皮肤、隐形眼镜、抗凝血材料及透析膜等生物医学材料的可能性。聚乳酸(PLA)是以乳酸为单体经化学合成的新型生物降解高分子材料,具有无毒、无刺激性、生物相容性好等特点,不污染环境,是目前最具有发展前景的可生物降解高分子材料,聚乳酸在组织工程中的应用极为广泛,在骨组织再生、人造皮肤、周围神经修复等方面均可作为细胞生长载体使用,并取得令人满意的结果。本文以丝素与聚乳酸以(2:8、4:6、6:4、8:2)(w/w)的比例湿法纺丝,对纺制的丝素/聚乳酸共混纤维进行扫描电镜(SEM)、X-衍射、差示扫描量热(DSC)、红外光谱分析,以YG004A型单纤维电子强力仪分析力学性能,并用扫描电镜观察分析了丝素/聚乳酸共混纤维的形态特征。此外,还探讨了放线菌酶对共混纤维的体外降解性能。结果表明,共混丝素纤维力学性能不如再生丝素,与再生丝素纤维相比,其断裂强度、断裂伸长率均比再生丝素纤维小很多,但是它的降解性能高于再生丝素纤维,较好解决了单纯丝素纤维难以降解的问题,有望在组织工程支架材料方面得到一定应用。更多还原

【Abstract】 The biodegradable materials have good biological compatibility and biological security, they can meet many kinds of biomedical function needs. Nowadays the focus on medical science of biodegradable materials has already developed from sewing, fixing materials to scaffolds of tissue engineering .Silk fibroin(SF) is a kind of natural polymer materials. it has good biological affinity, no toxicity to the organism , no stimulating quality ,it has already been used in seaming of the surgery, food additive and cosmetics. researchers point out that it would have been applied to the artificial skin ,contact lenses, anticoagulant material, dialysis membrane and cell culture scaffolds.Poly(lactic acid, PLA) is new biodegradable high polymer material of taking the lactic acid of monomer by chemical synthesis, with no toxicity, no stimulating quality and good biological compatibility, and not polluting the environment. PLA will be widespreadly used in tissue engineering, obtain the satisfying result in the bone tissue regeneration, the artificial skin, the peripheral nerve and so on.更多还原