【作者】 林诗富；

【导师】 李良栋； 陈卫衡；

【作者基本信息】 贵阳中医学院 ， 骨伤科， 2006， 硕士

【摘要】 目的：比较两种不同中医治法对糖皮质激素致实验性非创伤性股骨头坏死症的预防作用，为在临床对该病高危人群实施预防提供理论依据和应用指导。方法：68只健康成年白来航鸡，随机分为5组。A组为正常对照组；B组为模型组，按5.2mg／kg体重胸肌注射甲基氢化泼尼松琥珀酸钠，每周一次；C组为阳性对照组，在B组基础上每日口服洛伐他汀；D组为健脾化痰、活血通络组，在B组基础上每日口服健脾化痰、活血通络药；E组为温肾利水化痰、活血通络组，在B组基础上每日口服温肾利水化痰、活血通络药。按上述方法，造模的同时，灌胃给药，连续15周，于用药后8、14W翼下静脉取血，分别检测凝血、血液流变学指标和血脂指标，于用药后8、15W取材，肉眼观察股骨头大体情况，然后取股骨头、肝做病理组织学检测。结果：1、大体观察：A组全身状况明显好于其它各组，体重保持实验前体重，B组体重下降至第3周后开始回升并维持在第1周末水平，E组在前6周体重持续下降，6周后逐渐上升至第1周末水平。B、C、D组基本维持在第1周末水平。2、组织病理学观察：A组正常，B组空骨陷窝数明显增多，骨小梁细疏，髓腔脂肪细胞增大、增多，肝细胞肿大脂肪变，结构不清，余组病变较B组减轻，空骨陷窝数B、C组明显多于其他组。3、血脂检测：B组明显高于各组，D组降脂作用最为显著。4、血液流变学检测：B组增加血液粘滞性显著，D组降低血液粘滞性最为明显。5、凝血检测：B组增高血液凝血明显，C、D、E组均有降低血液凝血的作用，以D组最明显。结论：健脾化痰、活血通络中药可有效预防激素性股骨头缺血性坏死的发生和发展，而温肾利水化痰、活血通络中药和西药洛伐他汀有一定的预防作用，但其作用不全面、不显著。更多还原

【Abstract】 Object: To compare two preventative effect’s of different Chinese medical remedy to glucocorticoid-induced experimental non-traumatic Osteonecrosis of femoral head in order to provide theory and application instruction for high-risk group of this disease in clinic. Methods: 68 white healthy adult hens were randomly divided into 5 groups. A group was normal control group; B group was injected 5. 2mg Methyl Prednisolone Sondium Succinate per kg body weight once a week in chest muscle as model group. C group was positive control group, which was orally administrated Lovastatin per day on base of B group; D group was orally administrated invigorating spleen to remove phlem and promoting blood circulation to remove meridian obstruction drugs on base of B group; E group was orally administrated warming kidney for duresis to dissipate phlegm and promoting blood circulation to remove meridian obstruction drugs on base of B group. According to above-mentioned methods, to duplicate model, at the same time was intragastric administration drugs for 15 weeks. To investigate blood clotting, haemorheology and blood fat in the 8th and 14th week by the use of veins bloods of wings; meanwhile in the 8th and 15th week to kill the hens in order to observe the situation of femoral head and to detect pathohistology of femoral head and livers. Results:1、In general observation: The whole body conditions of A group of which body weight was equal to the weight before experiment was better than others groups; the weight of B group gradually decreased until the 3th week after that the weight increased and maintained the level of the 1th weekend; the weight of E group continually更多还原