【作者】 杨阳；

【导师】 王彦田；

【作者基本信息】 河北医科大学 ， 中西医结合临床， 2006， 硕士

【摘要】 我国已步入老龄社会，衰老引发的一系列问题给社会和家庭带来了沉重的负担。延缓衰老成为了人们关注的焦点和研究的热点。 衰老是整个机体形态结构和生理机能的全面衰退，是一个动态的、复杂的过程。因衰老的成因复杂，影响其发展的因素很多，故观察指标应尽可能多样。其中脑细胞损伤，自由基的损伤，自身的免疫能力下降，血脂的升高已得到了广泛的认可。 自然衰老大鼠的衰老进程与人类衰老近似，可以作为可靠的衰老模型。我们根据参考文献及课题组成员的观察选用4、14、24三个月龄的正常大鼠进行观测比较，观察不同月龄大鼠各生理阶段的特点，探讨大鼠衰老的内在机制，为选择合适的月龄进行药物延缓大鼠自然衰老的研究提供实验依据。 我课题组临床应用加味青麟丸改善中老年人气虚血瘀浊停表现效果显著。以上一研究为基础，观测了加味青麟丸对不同月龄大鼠衰老指标的影响，验证了加味青麟丸是否具有延缓大鼠衰老的作用，推测其可能的作用机制，为其临床应用提供实验依据，并为延缓衰老选方用药提供新的思路和方法。本实验共分2个部分。 第一部分 大鼠自然衰老进程中相关指标的研究 目的：为选择合适的月龄进行药物延缓大鼠自然衰老更多还原

【Abstract】 Our society has stepped into the agedness stage. The trouble brought by senescence has become a heavy burden to our society and families. It is urgent to postpone senescence to us.Rencently, many experiments about senescence were done. Most of them use the D-galactose model rats, but this kind of model method ignorance the slowly process of senescence. The process of senescence of spontaneously old rats is similar to human being, so this kind of rat can be the appropriate model animal used in the experiments on senescence. In the process of rat senescence, different months old rats show different physiological functions and different biochemistry markers. The first research of this paper is about spontaneously old rats of 4-month, 14-month and 24-month. We try to learn the different traits of them, to suspect the possible senescent intrinsic mechanism, provide the experimental basis of appropriate month to study senescence. The second research is based on the first part. Through the experiment of giving Added Herbs’ Qinglin Pill, try to find if this formula can postpone senescence, if different group has different effects, suspect the possible internal mechanism, provide new thoughtway and method of更多还原