【作者】 李凯；

【导师】 封国生；

【作者基本信息】 吉林大学 ， 外科学， 2006， 硕士

【摘要】 目的:探讨fascin在胃癌中的表达及其临床意义。方法:用免疫组织化学方法检测76例胃癌组织,自身对照正常胃壁组织及其中53例淋巴结转移肿瘤组织中fascin表达,以及胃癌组织中nm23、C-erbB-2的表达。结果:正常胃壁组织无fascin表达,76例胃癌中有24例(31.6%)fascin表达阳性,而且其表达与胃癌病理类型(WHO分类、Lauren’s分型)、TNM分期、浆膜侵犯、淋巴结转移、远处转移、nm23表达及C-erbB-2表达等因素相关,与年龄、性别、组织分化、脉管癌栓等因素无关。在伴有转移的胃癌病例中,原发灶和转移淋巴结中fascin蛋白表达有相关性。结论: fascin蛋白在胃癌及其转移灶中呈阳性表达,与胃癌发生、局部发展和转移相关,并在胃癌及其转移灶中有表达连续性;fascin蛋白表达有助于胃癌侵袭转移的判断,有可能成为新的治疗靶点。更多还原

【Abstract】 Objective: To investigate the clinical significance of fascin expression in gastric carcinoma.Methods: Detect the expression of fascin in 76 tissues of gastric carcinoma, their own normal gastric tissues in contrast, and also the lymph nodes involved by gastric carcinoma in 53 cases thereinto with immunohistochemical stain. We also detected the expression of nm23 and C-erbB-2 in the tissues of gastric carcinoma.Result: There is no expression of fascin in normal gastric tissues. Fascin proteins are positive in 24 cases of the 76 gastric carcinoma, and they correlate with pathological style (WHO classification and Lauren’s typing)、TNM staging、serosal invasion、lymphatic metastasis、distant metastasis、the expression of nm23 and C-erbB-2, and so on. They don’t correlate with age、gender、histodifferentiation、cancer embolus in vessel and so on. The expressions of fascin in primary masses and their metastatic lymph nodes are consistent, in the cases with metastasis.Conclusion: The expression of fascin is positive in the更多还原