【作者】 王静；

【导师】 陈怀红；

【作者基本信息】 浙江大学 ， 神经病学， 2006， 硕士

【摘要】 【目的】 动态观察急性脑梗死患者血清白介素-1β(Interleukin 1β,IL-1β)、C-反应蛋白(C-reactive protein CRP)含量变化,探讨炎症因子在脑梗死发病机制中的作用,为脑梗死的抗炎治疗提供实验依据。 【方法】 抽取脑梗死患者发病3d内、7d和14d时的空腹静脉血,采用双抗体夹心酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)测定血清IL-1β的水平,免疫速率散射比浊法测定血清CRP水平。 【结果】 急性脑梗死患者3d内、7d和14d时血清IL-1β、CRP水平均显著高于正常对照组(P<0.05),对其动态观察发现,发病3d内水平最高,随时间推移及治疗的介入,炎症因子水平逐渐下降;更多还原

【Abstract】 Objective: To explore the functions of IL-lp and CRP in thepathogenesis of acute cerebral infarction.Methods: serum levels of IL-1β were measured by enzyme-linkedimmunosorbent assay (ELISA) , and CRP levels were detected by theImmune rate nephelometry.Results: serum levels of IL-1β and CRP within 7days , on the 7th dayand 14th day in patients with acute cerebral infarction increasedremarkably as compaired with the control group (P<0.05) .the levelswithin 7days also increased remarkably as compaired with the levels ofthe 7th day,and the levels of the 7th day increased remarkably ascompaired with the 14th day .There was a positive correlation betweenthe increasing degree of IL-lp and CRP,and also a positive correlationamong different infarct volumes (P<0.05) .Conclusions: IL-lp and CRP possibly play a key role in thepathogenesis of acute cerebral infarction, antiinflammatory drugsperhaps will become potential new therapeutic agents for acute cerebralinfarction.更多还原