【作者】 刘永兵；

【导师】 张爱伦；

【作者基本信息】 新疆医科大学 ， 老年医学， 2005， 硕士

【摘要】 目的:分析老年糖耐量低减患者心血管病危险因素的聚集情况。方法:根据83g葡萄糖耐量试验,将131例老年患者分为糖耐量正常(NGT)组,糖耐量低减(IGT)组,比较两组患者的心血管病危险因素的聚集性及冠心病、脑卒中的发病率。结果:(1)IGT组与NGT组相比,甘油三酯(TG)明显升高,高密度脂蛋白胆固醇(HDL-C)明显降低,差异具有统计学意义(P<0.05)。IGT组的收缩压(SBP)、舒张压(DBP)、体重指数(BMI)亦较NGT组明显增高,差异具有统计学意义(P<0.01),纤维蛋白原(FIB)无统计学意义(p>0.05)。(2)IGT组合并高血压、肥胖、血脂异常等各项心血管病危险因素的比例及≥两个危险因素(2RFs)的比例均明显高于NGT组(P<0.01)。(3)具有≥2RFs的IGT患者冠心病、脑卒中的发病率明显高于NGT组(P<0.05)。(4)存在≥2RFs的IGT患者其颈总动脉内-中膜厚度明显增加。结论:IGT患者已存在明显的心血管疾病(CVD)风险,是CVD的独立危险因素。该阶段已出现心血管病危险因素聚集的现象,冠心病、脑卒中的发病率明显增加,应对IGT患者给予积极干预治疗。更多还原

【Abstract】 Objective:To investigate the cardiovascular risk factor and their clustering in elderly persons of impaired glucose tolerance. Method: According to 83 g oral glucose tolerance test(OGTT),131 eldly subjects were divided into normal glucose tolerance(NGT)group, impaired glucose tolerance(IGT) group,to compare the cardiovascular risk factors and their clustering, the disease incidence of cardiovascular event.Result:(1)The levels of blood-lipid were higher in subjects with IGT than those in NGT, and triglyceride,HDL cholesterol were more marked(all P<0.05). Compared with NGT group,the mean values of systolic blood pressure,diastolic blood pressure, body mass index were significantly higher in those who with IGT(P<0.01).Fibrinogen was no difference (p>0.05) (2)Compared with NGT group,the proportion in subjects with IGT who concurrent hypertension, obesity,disturbances of lipid metabolism and ≥cardiovascular risk factor(2RFs) were significantly higher ( P<0.01).(3)The disease incidence of cardiovascular event in subjects with IGT who company with ≥2RFs were obviously higher than NGT ( P<0.05). (4) Carotid atherosclerosis indicated by intima- media thickness(IMT) were obviously higher in IGT who company with ≥2RFs.Conclusion:There were significantly risk of incident of CVD in subjects with IGT,IGT was a dependent risk factor of cardiovascular disease (CVD).The phenomenon of clustering of cardiovascular risk factors was found in IGT,the disease incident of CVD were obviously increased. Thus,the patients with IGT should be intervened actively.更多还原