【作者】 戴小军；

【导师】 刘利军；

【作者基本信息】 宁夏大学 ， 分析化学， 2005， 硕士

【摘要】 豆科植物甘草是中药中常用的药材。研究表明甘草的主要药理学活性物质是甘草酸及其糖苷配基甘草次酸,在体内代谢时,甘草酸在酶的作用下水解为甘草次酸而发挥药物的生物活性作用,但当长期大量使用甘草酸或甘草次酸制品时,会引起被称为假醛固酮增多症的副作用,其特征是钠潴留、钾排泄量增加,引起水肿、高血压、低血钾等一系列的副作用。为提高甘草次酸的药效,减少或消除其毒副作用,本论文对一些甘草次酸的衍生物进行了研究,共包括三个部分: 第一部分:甘草次酸的结构改造 1.在甘草次酸的3位和30位分别成酯 2.对甘草次酸11位羰基的还原反应进行了研究 3.利用计算机对氟取代甘草次酸的化产物结构进行了辅助设计 第二部分:甘珀酸钠与苦参碱类生物碱包合性能的研究 制备了一系列甘珀酸钠与苦参碱,氧化苦参碱,扑热息痛,右旋麻黄碱等的包合物,并对其药理活性进行了研究。 第三部分:过氧化脲制备工艺的优化及其在纺织品漂白中的应用 确定了过氧化脲生产的最佳工艺条件,同时研究了过氧化氢的循环利用情况。并对过氧化脲用于纺织品漂白情况进行了研究。更多还原

【Abstract】 Licorice is a kind of Chinese traditional herbal medicine, it’s used very common in Chinese drugs. Pharmacological activities of glycyrrhizin, a saponin of licorice root, and its aglycone, glycyrrhetinic acid have been studied extensively, and their effects of anti-inflammatory, antiulcerous and antiallergic have already reported by many articles. And administration of glycyrrhizin and glycyrrhetinic acid preparations in higher dosage for a long period has resulted in a side effect which is noted as pseudoaldosteronism inducing edema and hypertension in patients. This mineral corticoid-like action of glycyrrhizin and glycyrrhetinic acid producing Na ion retention and K ion excretion. To enhance the therapeutic activities of the mother compound and retain or remove the aldosterone-like properties at the same time, this thesis studied on some derivatives of glycyrrhetinic acid and consists of three parts:Part I: synthesis some derivatives of glycyrrhetinic acid1. To form esters using the group -OH, or -COOH of glycyrrhetinic acid,2. Investigated the reaction of 11-deoxo-glycyrrhetinic acid3. Some structure of fluoroglycyrrhetinic acid were designed and optimized by ComputerPart II: Study on Inclusion Complex of Carbenoxolone Sodium with Matrine, Oxymatrin, Paracetamol, and PseduoephedrineSome inclusion complex of carbenoxolone sodium and matrine (CS/OMT,CS/PCM,CS/PEC) have been synthesized for the first time and characterized by UV, IR,~1HNMR and XRD, and the pharmacological activity of the inclusion complex have also been studied.Part III: The preparation and application of urea peroxide as a bleaching agentThe methods of preparing urea peroxide and reusing mother liquor were studied. Process parameters such as concentration of urea peroxide, bleaching time and PH value were approached. Urea peroxide as a new kind of bleaching agent features high efficiency and no corrosion.更多还原