【作者】 岳建新；

【导师】 田福利；

【作者基本信息】 内蒙古大学 ， 有机化学， 2005， 硕士

【摘要】 蒙椴(Tilia Mongolica Maxim.)为椴树科(Tiliaceae)椴树属(Tilia L.)中生落叶乔木,是内蒙古地区典型树种。椴树花、皮和树叶具有抗病毒和抗菌活性,最近的研究发现,蒙椴具有抑制光肩星天牛的作用。为了寻找蒙椴树皮中抗天牛的活性成分,本文对蒙椴的化学成分进行了研究。 本文对蒙椴树皮进行室温浸泡提取,对提取物利用常规硅胶柱层析、制备薄层层析、重结晶等技术进行分离纯化,从中分离得到了6个化合物,通过理化常数、红外光谱、质谱、核磁共振氢谱、碳谱和二维核磁的DEPT、HMQC、HMBC和H,H—COSY等数据并结合文献分析鉴定其结构,分别为β—香树脂醇乙酸酯(Ⅰ)、计曼尼醇乙酸酯(Ⅱ)、羽扇豆醇(Ⅲ)、三棕榈酸甘油酯(Ⅳ)、胡萝卜苷(Ⅴ)、(β—D)3′,5′—二(4—氯苯甲酰)胸腺嘧啶脱氧核苷(Ⅵ)。化合物Ⅱ、Ⅲ、Ⅳ、Ⅴ为首次从本属植物中分离的已知化合物。更多还原

【Abstract】 Tilia Mongolica Maxim, is a member of Tiliaceae family. Its bark, leave and flower were utilized for treatment of many disease. Recently, it was reported that T. Mongolica has inhibiting effect to Anoplophora glabripennis.In present study, by extracting the bark of T. Mongolica using a series of organic solvents respectively, different kinds of extracts were obtained. Six compounds were isolated from the ethyl acetate extracts by utilizing column chromatography, preparative TLC and recrystallization techniques. The complete structures of compounds were identified by IR, 1D and 2D NMR( ¹H NMR, ¹³C NMR, DEPT, HMQC, HMBC, ¹h,¹H-COSY) data and literatures. They are β -amyrin acetate（ Ⅰ ）, germanicol acetate （ Ⅱ ）, lupeol （ Ⅲ ）, propane-1,2,3-triyl tripalmitate （Ⅳ）, daucosterol（ Ⅴ ） and 3-D thymidine 3’ ,5’ -di （4- chlorobenzoate）（ Ⅵ）. Among them, Ⅱ, Ⅲ, Ⅳ and Ⅴ are known compounds isolated from the genus for the first time.更多还原