【作者】 胡合姣；

【导师】 潘远江；

【作者基本信息】 浙江大学 ， 有机化学， 2005， 硕士

【摘要】 卫矛属植物是一类重要的天然药用资源,在世界各地均有分布,在我国民间作为药物使用有着悠久的历史,主要用于抗肿瘤、抗炎、抗菌等。 本文对卫矛属药用植物常春卫矛中化学成分进行了化学研究,运用色谱与波谱技术对其化学成分进行了提取、分离与结构鉴定,共得到14个化合物,其中9个为五环三萜;对其中部分五环三萜化合物进行了二维核磁共振波谱学研究。具体研究内容如下: 1.从常春卫矛中分离得到的1个新的三萜化合物,运用质谱(ESI-MS)、核磁共振(1D,2D NMR)、红外光谱(IR)和紫外光谱(UV)等现代波谱技术,参考相关文献资料确定了该化合物的结构为28-羟基-木栓烷-3-酮-29-羧酸(28-hydroxy-friedelin-3-one-29-acid)(化合物(?)), 2.从常春卫矛中分离得到的5个已知木栓烷型五环三萜,利用现代波谱技术,并参考文献数据,确定了它们的结构分别为:3-木栓酮(化合物(?)),木栓烷-3-酮-28-醛(化合物(?)),木栓烷-28-羟基3-酮(化合物(?)),木栓烷-29-羟基3-酮(化合物量(?)),木栓烷-30-羟基-3-酮(化合物(?))。 3.从常春卫矛中分离得到的3个齐敦果型五环三萜。利用现代波谱技术,结合化合物的理化性质,并对照参考文献,确定了它们的结构分别为:3β-甲氧基-齐敦果-18-烯-11-酮,齐敦果-12-烯-3,11-二酮,28-羟基-齐敦果-12-烯-3,11-二酮。 此外,论文还对木栓烷型五环三萜化合物的结构与核磁谱学特征进行了研究与总结。更多还原

【Abstract】 The plant of Euonymus, which is distributed widely in the world, belong to an important natural officinal resource and has been used to treat with tumor, inflammation, bacterial et al for thousands of years as Chinese folk medicine in our country.In this paper, the chemical constituents from Euonymus hederaceus were phytochemically investigated. 14 compounds were isolated from this plant and the structure of 9 compounds was determineted, among them, 6 compounds is friedelin-type triterpenoids and 3 is olean-type triterpenoids, this work includes:1. A new triterpenoid was isolated and its structure was established as 28-hydroxy-friedelin-3-one-29-acid (compound 1) on the basis of spectral evidences in combination with the reported data in literature.2. Five known friedelin-type triterpenoids were isolated and the structures were identified with the help of spectral evidences and literature data. They are 3-friedelone, 3-oxo-28-friedelanal, 28-hydroxy-3-friedelanone, 30-hydroxy -3-friedelanone, and 29-hydroxy-3-friedelanone, respectively.3. Three known olean-type triterpenoids were isolated, and the structures were identified with the help of spectral evidences and literature data. They are 3β-methoxyolean-11-oxo-18-ene, Olean-12-ene -3, 11-dione, 28-hydroxyolean-12-ene-3, 11-dione, respectively.In addition, the relationship of NMR data-structural characteristics of friedelin-type pentatripenoids were summarized.更多还原