【作者】 王刚；

【导师】 刘金同；

【作者基本信息】 山东大学 ， 精神病与精神卫生学， 2005， 硕士

【摘要】 目的:探讨精神分裂症病人在IVA(Integrated Visual and Auditory)持续操作测试中的反应控制能力、注意力等,并与健康人进行比较,从而量化精神分裂症病人的认知功能损害,并进一步探讨其认知功能与疾病严重程度的关系。 方法:将41例首次发病符合CCMD-3精神分裂症诊断标准的精神分裂症病人作为研究组,在病人未经任何治疗前,即对病人进行IVA持续操作测试和简明精神病量表(BPRS)、阴性与阳性症状量表(PANSS)的评定。同时将41名无认知功能障碍的健康人作为对照组,进行IVA持续操作测试。将所有研究资料整理后,输入SPSS数据库,根据资料的性质应用SPSS13.0统计软件进行分析。 结果:1.反应控制:①精神分裂症病人的STMVQ与正常健康人无差别,而反应控制的其余各项指标,分裂症病人都显示出了异常。②反应控制商数异常率,两组的STMVQ异常率差异无显著性(P>0.05),精神分裂症病人的其余8个反应控制商数异常率极显著高于正常人(P<0.001)。③反应控制各指标均与BPRS总分、缺乏活力因子分以及PANSS阴性量表分、反应缺乏因子分显著负相关(P<0.05),而反应控制的部分指标,如FSRCQ、ARCQ、CONAQ、STMAQ等,与BPRS思维障碍、敌对猜疑因子分以及PANSS阳性量表分、思维障碍因子分亦显著负相关(P<0.05)。2.注意力:①与正常健康人比较,精神分裂症病人各注意力指标均降低,差异均具有极显著性(P<0.001)。②精神分裂症病人的注意力商数异常率均高于正常人,差异均具有极显著性(P<0.001)。③精神分裂症病人注意力各项指标与PANSS阳性量表分显著负相关(P<0.05),大部分注意力指标与BPRS总分、缺乏活力、思维障碍因子分,以及PANSS阴性量表分、反应缺乏因子分显著负相关(P<0.05)。 结论:精神分裂症病人的反应控制能力、注意力较正常健康人均有不同程更多还原

【Abstract】 Objective: To compare the response control and attention of schizophrenic patients with that of the healthy controls by Integrated Visual and Auditory (IVA) continuous performance test. To quantitate the impairment of cognitive function in patients, and to explore the relationship between cognitive function and the severity of the disorder.Method: A total of 41 inpatients with first-episode schizophrenia who met the diagnostic criteria of CCMD-3 were studied. The Brief Psychiatric Rating Scale (BPRS) and the Positive and Negative Syndrome Scale (PANSS) for schizophrenia were administered to assess the general mental status of patients before they received any treatment. At the same time, the IVA continuous performance test was used to assess the cognitive function of the patients. 41 healthy control subjects who have no cognitive function disorder also received the IVA continuous performance test. The data were analyzed with SPSS13. 0.Results: 1. Response control: ① All the indexes of the response control showed abnormalities in patients with schizophrenia except for STMVQ. ② There was no difference between the two groups for abnormal rate of STMVQ (P>0. 05), but the abnormal rates of all other response control quotients in patients with schizophrenia were significantly higher than those in the healthy controls (P<0. 001). ③ The indexes of response control were significantly negatively correlated with the total or decreased activity BPRS scores, and negative or lack of reaction PANSSscores (P<0. 05). Some indexes such as FSRCQ, ARCQ, CONAQ, and STMAQ were significantly negatively correlated with the BPRS score of thinking disturbance, hostility, and PANSS scores of positive symptoms and thinking disorder. 2. Attention : ?Comparing with the healthy controls, the indexes of attention in patients with schizophrenia were reduced significantly (P<0. 001). ?The abnormal rates of all attention indexes were significantly higher than that of the healthy people (P<0. 001). (3) All the attention indexes in schizophrenic patients were negatively correlated with the positive symptom score of PANSS(P<0. 05); most of the attention indexes were negatively correlated with total, decreased activity BPRS scores, thinking disturbance scores, and negative symptom, lack of reaction PANSS scores(P<0. 05).Conclusions: In comparing with the healthy people, schizophrenic patients indicate some impairment in response control and attention, and the impairment correlates with the severity of the disorder.更多还原