【作者】 龚华俊；

【导师】 杨小平；

【作者基本信息】 北京化工大学 ， 材料学， 2005， 硕士

【摘要】 聚乳酸/羟基磷灰石骨修复复合材料一直都是研究的热点。该复合材料最大的优点在于可以通过改变羟基磷灰石在复合材料中的组分、粒径以及分布情况设计出具有良好的生物性能、力学性能和降解性能的骨组织支架材料。但是目前传统的聚乳酸/羟基磷灰石类复合材料还不能完全满足理想骨组织支架材料的要求。有关碳纳米管及其复合材料在生物材料中的应用已经得到了广泛的关注,碳纳米管具有高的表面能和突出的力学性能,并能促进细胞和复合材料之间的粘合,因此碳纳米管可能成为骨组织支架材料有效的增强体。 通过阳极氧化对多壁碳纳米管表面进行处理,使其表面富含极性官能团;然后在多壁碳纳米管存在的情况下进行超声辅助原位湿法合成制备多壁碳纳米管/羟基磷灰石纳米复合材料。通过该法制备的纳米复合材料和纯羟基磷灰石具有相同的化学成分和较高的结晶度。 采用溶液—超声共混法制备聚乳酸/多壁碳纳米管/羟基磷灰石复合膜,通过静力学实验和动力学实验研究了多壁碳纳米管/羟基磷灰石纳米粒子质量含量对复合材料结构与机械性能的影响。随着纳米粒子质量分数的增加,复合膜的拉伸强度呈下降趋势;拉伸模量和储能模量呈现先下降后上升的趋势;玻璃化转变温度则呈现不断上升趋势。更多还原

【Abstract】 A new class of materials based on organic and inorganic, such as polylactide(PLA) /hydroxyapatite(HA), has obtained more attention recently. The greatest advantage of the hybrid composites is that they offer the possibility of tailing its properties by playing with the volume fraction of the discontinuous, dimension of the particles and its orientation. However, the conventional hybrid composites can not meet the need of natural bone. The ideal bone tissue engineering materials should provide a connection between nanoscale ang microcale to meet the require of different cells. Rencently the application of carbon nanotubes(CNTs) and its composites in biomaterials has received considerable attentions. CNTs possesses several unique properties, such as high surface energy and outstanding mechanical properties, which suggests the materials may be ofvalue in the development of novel devices for bone tissue engineering scaffold.Multi-walled carbon nanotubes (MWNTs) were firstly treated by anodic oxidation, which resulted in various functional groups such as C—O, CO and O — C=O on the surface of oxidized MWNTs. Then the MWNTs/Hydroxyapatite (HA) nano-composites (MWNTs content: 3wt%) were in situ synthesized by wet method with the help of ultrasonic. Because of the strong interaction between the functional groups on the surface of MWNTs and Ca2+ in HA, the obtained HA nano-particles were deposited onto the surface of oxidized MWNTs. The prepared nano-composites have the same component and crystallinity.PLA/MWNTs/HA composite membranes were prepared by solution casting method. The effect of MWNTs/HA nanoparticle content on mechanical and dynamic was tested using tensile tests and dynamic mechanical analysis(DMTA). As the MWNTs/HA nano-composites content increased, the tensile strength of composite membranes decreased because of the agglomeration of MWNTs/HA nano-particles, tensile modulus and storage modulus first increased then decreased, and the glass transition temperature increased due to polymer chain adsorption and immobilization onto the MWNTs/HA nano-particles.The PLA/MWNTs/HA hybrid nanofibers were electrospun under the voltage of 18Kv and the capillary to target distance of 4cm using更多还原