【作者】 陈金龙；

【导师】 朱昌青；

【作者基本信息】 安徽师范大学 ， 分析化学， 2005， 硕士

【摘要】 光学分子传感器是“分子识别”在分析科学新的发展形式下的一种应用形式,由于其在环境和生物的微观系统的组成、结构和衍化信息探索方面的重要贡献,业已成为目前国际前沿性研究热点之一。本文在对传统光学分子传感器的研究总结的基础上,开展了“光学分子传感器”的研究工作,本文成功地借鉴几种新的传感器的设计策略构建了几种光学分子传感器体系,其传感的目标物种涉及阴离子、金属阳离子、酸度pH。论文共分七章,分别包含以下主要内容: 第一章为绪论。首先简要介绍了光学分子传感器的基本概念、研究现状和发展趋势;接下来,对这些相关研究进行总结,最后结合本实验室的条件,提出本论文的研究设想。 第二章介绍了实验所用的试剂、仪器及所涉及的几种化合物的合成。 第三章介绍了氟离子选择性显色分子传感器的研究。本章借鉴有机化学制备反应中常用的保护与脱保护原理,运用到分子传感器的设计、应用中。,设计、制备、表征了一种新型的选择性氟离子分子传感器,即把带有羟基官能团的花菁染料作为显色传感器的指示基团,并成功用于水相阴离子氟的选择性识别传感。这种传感器的设计为实现水相的小分子和离子的传感和识别提供了新的思路,在设计原理和分析方法上具有一定的创新。 第四章介绍了分辨型二价铁的自旋荧光传感器的设计与应用研究本章分列为两部分。将氧化还原反应这一人们最为熟悉的基本概念引入到传感器的设计中来。利用稳定的氮氧自由基对芳烃类单重激发态有效猝灭的独特性质。把长寿命,量子产率高、共扼的芘荧光团作为指示基团,设计、制备两种分辨性的二价铁的荧光传感器。 第五章介绍了分辨型量子点荧光重金属、过渡金属阳离子(Heavy and Transition更多还原

【Abstract】 Optical molecular chemosensors (OMCS) has emerged in the field of analytical chemistry as an application form on the research on molecular recognition, Research on OMCS has been one of the current scientific fronts due to its unique contributions in probing composition, structure or evolution of environmental of microbiological systems. Along this line, the research on several novel types of optical molecular chemosensors was conducted and a series of optical molecular chemosensors has been developed in this dissertation based on the traditional design strategies of optical chemosensors, in which a wide range of chemical substances including anion, metal cations, acidity pH was involved as analytical targets. This dissertation consist of seven chapters summarized in the following: In chapter1, first a general introduction to the basic conception and research status quo, development trend of OMCS was presented. Second, we investigate and summarized the relative research reports and cultures about OMCS. Finally, based on the concerning updated development and our experiment institutions, the research proposal for this dissertation was presented. In the chapter 2, the reagents, apparatus and synthesis of some probes compounds by this dissertation were described. In chapter 3, the common principle of the protection and de-protection in the organic synthesis reaction was conducted to design and application of OMCS. First, a cyanine dye involving hydroxyl as colorimetric sensing signal group, we designed and synthesized a novel colorimetric sensor for fluoride ion. The proposed method has been successfully applied for determination for fluoride in local rainwater samples. This design offers a new strategy on sensors for small gas molecules and anions in aqueous. In chapter 4, two types of “differential optical molecular chemosensors”(“DOMCS”) for iron (II) were described. The most familiar conception on redox reaction was conducted to DOMCS design. As well known, stable nitroxide radical is a series of quenchers for aromatic fluorophore by single excitation state. Two kinds of DMOCS were designed and synthesized by covalently linking TEMPO to pyrene fluorophore with long lifetime, high fluorescence quantum yield via ester bond. In chapter 5, CdS QDs funtionalized with L-cysteine was synthesized by one step. These QDs only exhibited deep trap emission (defection emission). Based on the different and sensitive optical responded to heavy and transition metal (HTM), a basic interaction between HTM and QDS DMCS was studied. These experiment found was hoped to be HTM sensor for application in real tissue such as cell. In chapter 6, CdS QDs were synthesized with one new mean. These QDs exhibited two different optical signals: scattering emission and deep trap emission in visible region. Based on the optical signals different dependence on the pH value of buffer solution system. Then, the wavelength-ratiometric method for pH sensing in the range of cytosolic pH of cell 6.8-7.4 was proposed. The mechanism of the CdS QDs optical dependence on pH was studied. In chapter 7, the characteristic and innovation of the dissertation were given.更多还原