中汇痛风定胶囊对急性痛风性膝关节炎家兔模型滑膜组织白细胞介素8（IL-8）和肿瘤坏死因子α（TNF-α）影响的实验研究

【作者】 刘挺；

【导师】 刘元禄；

【作者基本信息】 辽宁中医学院 ， 中医骨伤科学， 2005， 硕士

【摘要】 目的:观察中汇痛风定胶囊对急性痛风性膝关节炎家兔模型滑膜组织中白细胞介素8(IL-8)和肿瘤坏死因子(TNF-α)表达的影响。方法:按照McCarty DJ造模方法建立急性痛风性膝关节炎家兔模型,造模2h后取滑膜组织,应用ELISA法测定IL-8和TNF-α含量。结果:①模型组IL-8和TNF-α的水平明显高于正常组(P<0.01):②痛风定组IL-8和TNF-α水平明显低于模型组,差异显著(P<0.01)。结论:①IL-8和TNF-α在急性痛风性关节炎发病过程中起重要作用;②中汇痛风定胶囊能够显著抑制急性痛风性膝关节炎家兔模型滑膜组织IL-8和TNF-α的表达,对急性痛风性关节炎具有良好的治疗作用。更多还原

【Abstract】 Object: To determine whether zhonghuitongfengding leads to changes in IL-8 and TNF-alevels in synovium in an experimental rabbit models. Methods: create the model of monosodium urate crystal-induced rabbit arthritis according to Mc Carty D J.Total .IL-8 and TNF-αwas assessed through method of ELISA after synovium was isolated 2h later .Results: ①The levels of IL-8 and TNF-αin model group are significantly higher than that in normal group(p<0.01). ②The levels of IL-8 and TNF-αin zhonghuitongfengding group are significantly lower than that in model group(p<0.01) Conclusions: ①IL-8 and TNF-αhave most important function in synovium of induced rabbit actue arthritis . ②tongfengding could significantly reduce the level of IL-8 and TNF-ain synovium of induced rabbit actue arthritis and had better preventing and curing effect.更多还原