【作者】 李萍；

【导师】 胡宛如；

【作者基本信息】 中国医科大学 ， 儿科学， 2005， 硕士

【摘要】 目的 探讨应用柔红霉素(DNA)治疗小儿急性白血病的心脏毒性。 方法 总结了68例接受柔红霉素治疗的急性白血病患儿的临床资料,并对发生心脏毒性的患儿按发病类型和药物累积量进行分组分析。 结果 68例患儿中有9例出现心脏毒性,并以慢性和迟发性心脏毒性为主,年龄越小,累积量越大,心脏毒性发生率越高。 结论 对于应用柔红霉素治疗的白血病患儿,应严格控制药物累积剂量,定期对心脏进行药物毒性检测,长期随访以便及早发现心脏损伤。更多还原

【Abstract】 ObjectiveTo investigate the daunorubicin-induced(DNR) cardiotoxicity in the treatment of acute leukemia of children .MethodsWe Collected 68 cases of pediatric acute leukemia that were treated with DNR and choosed the children with cardiotoxicity.We divided them into groups and analyzed according to clinical types and accumulated doses.Result9 of the 68 cases show cardiotoxicity, in which chronic secondary cardiotoxicity is common . The younger the child is ,The more the accumulated dose is , the higher the incidence of cardiotoxicity is.ConclusionFor the children treated with DNR, accumulated doses should be controlled accurately and drug toxicity monitoring should be made regularly. Long-term follow-up should be neccesary, so that heart injury can be detected promptly.更多还原