【作者】 冯卫；

【导师】 唐力；

【作者基本信息】 中国医科大学 ， 影像医学与核医学， 2005， 硕士

【摘要】 目的 通过超声检测2型糖尿病患者股动脉内膜-中层厚度(intima-mediathickness,IMT),肱动脉内皮依赖性舒张功能,探讨各指标在2型糖尿病患者外周动脉病变中的早期诊断价值及血糖、血脂与下肢血管病变的关系。 方法 将2型糖尿病患者46例按照是否合并下肢血管病变分成二组,将正常对照组24例为一组,共分三组。应用彩色多普勒超声诊断仪分别测量各组的股动脉IMT值以及血流介导的肱动脉内径扩张值(flow-mediated dilation,FMD),并收集各组患者的空腹血糖、血脂等值,然后将各组指标对照分析。 结果 糖尿病患者未出现下肢血管病变组与正常对照组比较,股动脉IMT值略增高,但无统计学意义(P>0.05),而肱动脉FMD值却有明显降低(P<0.01),有显著性意义;FMD值与糖尿病患者的年龄有相关性,r值为-0.421(P<0.05);与IMT值呈显著负相关,r=-0.745(P<0.05);与甘油三酯呈轻度负相关,r值为-0.32。两患病组临床资料对比显示:两组空腹血糖、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)比较均无统计学意义(P>0.05),而病程、血浆甘油三酯(TG)比较有显著统计学意义(P<0.05)。更多还原

【Abstract】 ObjectiveTo discuss the early value of femoral artery intima - media thickness and braohial artery endothelium - dependent dilation measured with ultrasound in the diagnosis of peripheral arterial disease of type 2 diabetic patients and the relationships between the blood suger , lipids and lower limb arterial disease.MethodsForty - six type 2 diabetic patients were divided into two groups according to lower limb vascular complication and compared with normal controls twenty -four cases. IMT and flow mediated dilation ( FMD) were detected by ColourDop-pler flow imaging. PG,TG,TC,HDL,LDL in plasma were tested for every case in the fasting state and compared with each group.ResultsIMT of femoral artery were increased and there were no significant differ-ences(P<0. 05) in diabetic patients without lower limb complication and normal controls,but FMD were significant decreased (P <0.01). Meanwhile,FMD was negative correlated with age of the diabetic patients (r= - 0.421, P < 0.05) and was significant negative correlated with IMT( r = - 0.745, P < 0.05). each更多还原