【作者】 戴琦；

【导师】 姚玉峰；

【作者基本信息】 浙江大学 ， 眼科学， 2005， 硕士

【摘要】 目的: 观察常规体检人群周边前房深度及其和窄房角、中央前房深度、眼轴长度、晶体厚度、角膜厚度、屈光状态及眼压等的关系,以及观察常规体检随访人群周边前房深度和房角在一定时间内的变化情况。 对象方法: 2003年10月至2005年2月在我院(浙江大学医学院附属邵逸夫医院)接受常规体检的人群,及其中在这段时间内来我院接受再次体检的人群。按照Van Herick周边前房深度分级法,使用裂隙灯显微镜观察其周边前房深度,Van Herick周边前房深度分级小于3级,即周边前房深度房角≤1/2角膜厚度的受检者,进一步接受包括眼压、屈光、中央前房深度、眼轴、晶体厚度、角膜厚度等指标的检查。并对两次检查结果进行比较和统计学分析。 结果: 2003.10.27～2005.02.28共16个月中:,有11562人(23124眼)参加体检。其中男性7534人(15068眼),女性4028人(8056眼)。浙江大学硕士研究生学位论文、乞n Herick分类法3级以下者即周边前房深度蕊1/2角膜厚度的共有1922只眼(占总体检眼数的8.31%)。1236只眼接受眼压、屈光、A超(包括眼轴长度、晶体厚度、中央前房深度、角膜厚度)及房角镜的检查。不同年龄段组间、乞n Herick周边前房深度分级的构成差别有统计意义(P<0.001)。周边前房深度为3级以下的女性高于男性,差异有显著性(P<0 .001)。眼轴与周边前房深度的关系呈正的直线相关(二0.249,P<0 .001);中央前房深度与周边前房深度的关系呈正的直线相关份0.235,P<0.001);屈光度与周边前房深度分级呈负的直线相关(二一0.076,P=0.001)。周边前房深度与晶体厚度(p一0,482),角膜厚度(p=0.160),眼压(p=o:267)无相关关系。房角镜检查发现1221眼中%眼为可关闭房角(7.86%),年龄、周边前房深度与可关闭房角的关系均有统计意义(P<0.001)。 共有380人(760眼)再次来我院随访,其中男性268人(536眼),女性112人(224眼),平均随访时间10.84士2.33个月。原、乞n Herick分类法4级的681只眼中有29只眼(4.3%)周边前房深度进一步变浅;原未接受治疗的、乞n Herick分类法3级的55只眼中有9只眼(l 6.4%)周边前房深度进一步变浅。总共有38只眼(5.1%)的周边前房深度有进展,其年龄段分布为:①30一39岁2眼,占该年龄段人群的0.8%;②40一49岁21眼,占该年龄段人群的7.0%;③50一59岁巧眼,占该年龄段人群的13.9%。三组间有统计学意义伊<0.05)。首次体检周边前房深度3级以下组的进展眼比例9/55(16.4%)与4级组的比例19/681(3.0%)有统计学意义(P二0.04)。进展人群的眼轴、中央前房深度、晶体厚度、角膜厚度、眼压和屈光两次检查结果无明显变化。随访时间内没有一眼发展为可关闭房角。—3—更多还原

【Abstract】 Purpose:To investigate the prevalence and features of shallow anterior chamber in a population of routine health examination And to observe the progress of limbal anterior chamber depth and gonioscopy by investigation this re-examinated population of routine health examination in our hospital.Subjects and methods:The object is a population who had received routine health examination in our hospital from October 2003 to April 2004 and those who had received re-examination in this time. Each subject underwent the following investigations: visual acuity, slit lamp examination and slit-lamp assessment of anterior chamber depth according to the Van Herick grading method involved assessment of the limbal anterior chamber depth as a fraction of the corneal thickness(CT). Enrolled patients whose limbal chamberdepth were less than or equal to l/2CT(Van Herrick Grades 2, lor Slit) were examined by non-contact tonometry, A ultrasound scan, examination of refraction and gonioscopy. And we contrast the data of two tims.Results:Totle number of these people is 11562 persons(23124 eyes). 1922 eyes(8.31%) were termed Van Herrick Grades 3, 2, 1 or Slit. Actually, 1236 eyes were examined. The prevalence of shallow anterior chamber increased significantly with age using chi-square test (P<0.001) . Axial oculi and axial anterior chamber depthand diopterlinearly increased with limbal anterior chamber depth. Totle number of the re-examination people is 380 persons(760 eyes).681 eyes were fractionated as Van Herrick Grades 4.Among this, 29eyes has progress of limbal chamber depth. The number of Van Herrick Grades 3 eyes which had not received any therapy is 55. Among this ,there’s 9 eyes has progress of limbal chamber depth. Totle 36 eyes of these 38 eyes which has progress are over 40years old. And the progress rate of Van Herrick Grades 4 eyes is significantly lower than it in Van Herrick Grades 3 onesConclusion:The limbal anterior chamber depth changes shallower with the age. Shallow limbal anterior chamber is more common in females. The age of eyes which has progress is almostly between 40 to 60. The possibility of progress in Van Herrick Grades 3 eyes is more thanVan Herrick Grades 4 ones. The time of follow-up is not enough.更多还原