【作者】 胡丰华；

【导师】 万怡灶； 王玉林；

【作者基本信息】 天津大学 ， 材料学， 2004， 硕士

【摘要】 本文采用RTM工艺制备C3D/EP复合材料,进行了弯曲、剪切、冲击、拉伸等力学性能实验,分析了编织参数对各项性能的影响,并制备出形状复杂的C3D/EP复合材料骨折内固定物——髓内针和人工锥板,优化了RTM工艺参数。对几种树脂基复合材料进行了细胞毒性实验,采用直接接触法将3T3细胞直接接种材料表面、培养并对细胞生长形态进行观察,标本固定后进行SEM分析;并对这几种材料进行了溶血实验,分析了材料对血浆游离血红蛋白(FHb)、结合珠蛋白(Hp)两项人体血液指标的影响;在体外实验基础上,对C3D/EP复合材料内固定物进行了山羊的大动物体内植入实验。结果表明C3D/EP复合材料表面细胞生长形态正常,帖附良好,优于其它几种树脂基复合材料;C3D/EP复合材料对人血的FHb和Hp两项指标影响均在正常值范围内;动物体内植入后无明显炎症反应,骨组织生长良好,并与种植物结合紧密。C3D/EP复合材料力学性能比传统骨折固定材料与人骨更匹配,具有良好的生物相容性。在骨折内固定器械领域有极大发展潜力。更多还原

【Abstract】 3D-braided carbon fiber reinforced epoxy composites had been prepared for bone fracture fixation by RTM process. Mechanical properties such as bend, shear, impact and tensile properties of C3D/EP composites were investigated. Complex figured biomaterials-acus in the marrow and vertebra were made. RTM’s technological parameters were optimized.Cytotoxicity testing by direct cell contact method was carried on several resin matrix composites. Cytotoxicity was assessed by direct cell contact test 3T3 cell SEM morphology after contact with several resin matrix composites. Hemocompatibility were investigated by FHb and Hp of human body blood, On such foundation, implant tests were done after through implanting C3D/EP acus in the marrow and vertebra in goats.The results of the present study show that C3D/EP composites on direct contact did not induce any cytotoxic effects on 3T3 cell morphology, the FHb and Hp of human body blood after influenced by C3D/EP composites were equal in the normal value scope. No inflammatory reaction was found in goats. Bone tissue was combined with the composite closely and grew well.C3D/EP composites show better mechanical properties in contrast to traditional bone fracture fixation materials and have good biocompatibility. It is a kind of promising material for bone internal fixation.更多还原