【作者】 王秀霞；

【导师】 李季；

【作者基本信息】 中国地质大学 ， 分析化学， 2004， 硕士

【摘要】 核黄素是生物体不可缺少的 B 族维生素,目前我国只有湖北广济药业股份有限公司和上海迪赛诺维生素有限公司生产核黄素。为了使其产品与巴斯夫、罗氏等国际维生素巨头相比更具竞争优势,我们开展了把膜分离技术应用于核黄素生产后处理过程的研究,在简化工序的同时,回收流失的核黄素,降低生产成本,无废水排放,实现清洁生产。本文重点探讨了用无机微滤膜分离、浓缩核黄素氧化结晶底料和用有机纳滤膜处理末端水回收产品的技术参数。1、通过试验比较不同孔径的膜渗透通量的大小及其衰减幅度,确定采用 0.2μm 的无机陶瓷膜对核黄素氧化结晶底料进行分离、水洗和浓缩。2、重点研究了微滤膜和纳滤膜操作参数的适宜值。理想条件下,膜的通量随着压力、温度、流速的升高而增大。但本实验中,考虑到物料体系的特性以及膜本身的一些特点,得出微滤膜的最佳工作条件:压力为 0.2MPa,温度为 30℃,流速为 5.0m/s,浓缩倍数以不超过 4.4 倍为宜。在这种操作条件下,对核黄素氧化结晶底料进行分离、水洗和浓缩,其产品的各项质量指标均达到要求。纳滤膜的最佳工作条件:操作压力为 0.7～2.0 MPa,料液温度为 30℃,流量为 18L·min-1,浓缩倍数为 5.6 倍。在这种操作条件下,对预处理后的微滤滤液和氧化结晶上清液进行处理,每年可收回核黄素 150 吨左右,挽回经济损失 2000 万元左右;废水的 CODCr由原来的 24000mg/L 降到现在的 190mg/L,BOD 由原来的 8000 mg/L 降到现在的 30mg/L。 3.膜污染和膜清洗是膜应用中不可避免的问题。本文对微滤膜采取先碱洗后酸洗的清洗方案,其透水率恢复系数可达到 98.6%;对纳滤膜采取复合剂清洗方案,其透水率恢复系数可达到 99.1%。4. 本文还对核黄素的新旧两个工艺进行了设备投资、运行费用等的比较。新工艺在设备投资和运行费用与原有工艺基本持平的情况下,每年因回收核黄素就可产生 1950 万元的效益,其投资在 1 年的时间里就可收回;新工艺的收率为 92%,比原工艺提高了 12个百分点;新工艺的成本比原工艺降低了 13.3%。更多还原

【Abstract】 Riboflavin is one of the necessary B Vitamins for the organs. Now, only the Hubei GuangjiMedicine Corporation and Shanghai Desano Vitamins Corporation can manufacture riboflavin.To compete with those famous combines, such as BASF,Roche, the membrane separationmethods were used to deal with the downstream processing in the manufacture of riboflavin. Themembrane methods reduce the manufacture processes; recycle the dismissed riboflavin, reducingthe costs and achieve cleaner production. In this paper, the parameters of using inorganicmicrofiltration membrane methods to desperation, concentrate riboflavin oxide crystallizationand organic nanofiltration membrane to deal with waste water are described in detail. 1.According to compare the flux intensity and attenuation with membranes which havedifferent apertures, the best membrane dimension is 0.2μm. 2.In this paper, we emphasis on the best manipulation parameters of microfiltrationmembrane and nanofiltration membrane. In ideally conditions, the membrane flux increase withthe increasing of pressure, temperature and flow velocity. But in this experiment, because of thecharacterizes of materials and membrane, the best working parameters are as follows, thepressure is 0.2MPa, temperature is 30℃, flow velocity is 5.0m/s and the condense ratio should beless than 4.4 times. In these conditions, after watering, condensing and desperation of theriboflavin, the suitable products can be gotten. The best working parameters of nanofiltration areas follows, the pressure is 0.7~2.0MPa, the flow temperature is 30℃ ,the flow velocity is18L/min and the condense ratio should be 5.6 times. In these working conditions, after dealingwith the raw materials, we can recycle about 150 tons riboflavin per year and gain about more20,000,000 RMB per year. The CODcr of the waste water decrease from 24000mg/L to 190mg/Lnow and the BOD of waste water decrease from 8000mg/L to 30mg/L. 3.The pollution and clean of membrane are inevitable in the applications of membrane. Inthis paper the clean methods of microfiltration membrane are that clean the membrane by alkalifirstly and then using acid. After cleaning, the water filtration ratio is 98.6%, and after thecompound cleaning methods of nanofiltration membrane, the water filtration ratio is 99.1%. 4.In this paper, comparing the investments and costs of the new technics with the old, wefind that with the same investments and costs, about 19,500,000 RMB benefits can gain byrecycling riboflavin from waste water. And the investments can reward in about one year.Theyield of new technics is 92%,which is more than the old one by 12 per cent. And the cost of newtechnics is lower 13.3% than the old one.更多还原