【作者】 吕坤；

【导师】 金日光；

【作者基本信息】 北京化工大学 ， 高分子化学与物理， 2002， 硕士

【摘要】 以人类基因组测序为代表的生命科学和生物技术已经成为当前世界范围内最为前沿的研究热点，但是基因组研究并不能解决关于生命的一切问题。人体内多数生物高分子以一系列元素含水络合离子作为生物酶的活性中心，通过它们的催化激活动力作用来进行合成的。这些活性中心从本质上也控制着DNA的合成、复制和转录等行为，从而对人的生老病死起到了十分重要的作用。长期以来，生命科学和医学界只注意到个别微量元素的生理作用及它们和相关疾病的关系，而没考虑各种元素的整体分布对人体某器官和组织的健康与否所产生的影响。第四统计力学作者首先提出了生命动力元素群的概念和一整套理论的研究方法，本研究采用第四统计力学—JRG群子理论对人体器官、抗癌中药和心血管中药等的生命动力元素整体分布规律进行了系统研究。 本研究利用JRG群子理论对大量的实验数据进行分析，首次建立了生物体内元素分布的群子模型，提出了生物体生命动力元素分布的计算方法，并对群子参数R₁、R₂以及均匀性标度参数R₁·R₂的物理涵义做了进一步的阐明。北京化工大学硕士学位论文 本论文从原子序数和亲电强度标度理论出发，分别建立了不同的群子模型，用来研究生命动力元素的整体分布规律，结果表明:人体器官和组织、中药、抗癌中药、心血管中药分别呈现如下四种分布:轻度元素分布、较轻度元素分布、较重度元素分布、重度元素分布（根据原子序数Z）和低亲电强度分布、较低亲电强度分布、较高亲电强度分布、高亲电强度分布（根据亲电强度标度值毛）。 五行学说是中医学的一个重要的理论基础，但是由于中医学本身不能够提供现代的科学依据来证明五行学说的正确性，因此使得五行学说倍受冷落，本文通过对群子参数进行分析从而定量地考察了中医五行学说的科学性和必然性，揭示了人类器官和组织的元素分布的差异是五行学说科学性的本质基础。 根据传统的理论，阴阳中药的区分往往是建立在长期实践中所形成的定性唯象理论基础之上的，本文依据元素分布的群子模型（按亲电强度），首次提出了确定中药和器官阴阳分类的定量标准，即利用群子参数Rl进行界定，阳性中药和器官（Rl<6）、较阳性器官和中药 （6<R1<10）、较阴性器官和组织（10<Rl<13）、阴性中药和器官（Rl>13）。 本研究通过分析群子参数之间的关系，发现中药的阴阳属性和其性味存在着密切的对应关系，即低亲电强度分布的阳性中药（Rl<6）和较低亲电强度分布的较阳性中药（6<R1<l0）的性味主要是甘、辛、热、温，而高亲电强度分布的阴性中药（Rl>13）和较高亲电强度分布的较阴性中药（10<Rl<l3）的性味则主要是苦、咸、酸、寒。同时，竺旦竺里旦旦竺竺里旦旦旦竺旦旦旦旦些旦旦旦里竺旦旦旦旦旦旦旦旦竺竺竺旦旦竺旦旦旦旦旦旦竺里旦旦旦旦旦里旦旦旦旦旦旦旦旦 一2一北京化工大学硕士学位论文利用人体器官、组织和中药的群子参数之间的关系，对于中药的归经理论进行了系统研究，得到了定量的分析结果，即低亲电强度分布的阳性中药（R，<6）主要归于阳性器官（Rl<6），而高亲电强度分布的阴性中药（Rl>13）主要归于阴性器官（Rl习3）。 抗癌中药目前是吸引了最多研究目光的一大类中药，本研究发现那些属于低亲电强度分布的阳性中药（Rl<6）和高亲电强度分布的阴性中药（Rl>13）的抗癌性能较弱，而那些属于较低亲电强度分布的较阳性中药（6<R1<l0）和较高亲电强度分布的较阴性中药（10<Rl<13）则具有非常好的抗癌性能。 本研究采用第四统计力学分析了抗癌中药和心血管中药的有机化学成分和亲电强度之间的关系，从而进一步证实了生命动力元素的亲电强度是决定抗癌中药和心血管中药主要化学成分的内在原因。 如何定量的确定中药的具体药效是一个十分重要的问题，本文利用第四统计力学一JRG群子理论对于心血管中药的生命动力元素分布进行了深入研究，得到心血管中药的性味、药效和相应的群子参数之间的定量关系，这将为进一步开发新型药物奠定理论基础。更多还原

【Abstract】 The profundity and scope of research on the human being have been deepening with the investigation on the other things of the nature. The life science and biological technology with the Human genome Project (HGP) as representation are the most attracting research frontiers in the world. Most biopolymers in the body are synthesized under the effect of a series of elements hydration ions, which catalyze and power the synthesis of biopolymers. These active centers also control the synthesis, duplication and transcription of DNA in nature, thus they play very important role on almost all problems of human health. The physiological effects and the relationship between the individual element and relevant diseases have been studied for ages by the researcher in the life science and medicine field, but the relationship between the total elements distribution and the conditions of organs in the body has not been investigated. In this paper, the distribution of power elements of life in the body, anti-cancer Chinese herbs and cardiovascular Chinese medicines was systematically researched by exerting Fourth Statistical Mechanics -JRG sub-cluster theory. The significative quantitative results about distribution of power elements of life delivered in this research have not been reported in other literatures.The sub-cluster model of elements distribution is first proposed by analyzing the experimental data. And the truly physical meaning of sub-cluster parameter R1R2 and R1*R2, the homogenous scale of sub-clusters , is first set forth in the distribution of power elements of life inorganisms.The distribution law of power elements of life is investigated by using the sub-cluster models, which are founded according to the atomic number and the electrophilic intensity respectively. The result shows that the power elements of life in the body, anti-cancer Chinese herbs and cardiovascular Chinese medicines present four kinds of distribution as follows in terms of atomic number, the lightest elements distribution, lighter elements distribution, heavier elements distribution and the heaviest elements distribution. And it also has another four types of distributions according to the electrophilic intensity, namely low electrophilic intensity distribution, lower electrophilic intensity distribution, higher electrophilic intensity distribution and highest electrophilic intensity distribution.The Five-Element Theory is the groundwork of the Traditional Chinese Medicine (TCM), but some people regard the Five-Element Theory as unscientific and only a guess, and at the same time, the Traditional Chinese Medicine can not provide the modern scientific evidence to prove itself, consequently, little attention is paid to the Five-Element Theory. The correctness and inevitability of the Five-Element Theory are studied quantificationally by analyzing the parameters of sub-cluster. The result reveals that the difference in distribution of power elements of life is the essential foundation of the Five-Element Theory.Yin and Yang are the philosophical terms in TCM, and determining Yin and Yang is based on the qualitative theory founded through long-range practices. The quantitative criterion to classify the Yin and Yang of organs and Chinese herbs is first proposed in this article by investigating the electrophilic intensity. The Yin and Yang can be determined by the value of R1, a parameter of sub-cluster. Those organs and herbs are Yang when the value of R1 is less than 6 and comparatively Yang when R1 is 6 to 10. when R1 is over 13 ,those organs and Chinese medicines are Yin and comparatively Yin when R1 is 10 to 13.The close relationship between the property, action and the Yin ,Yangof herbs is first found by researching the parameters of sub-cluster. Those Chinese herbs with the low electrophilic intensity distribution and lower electrophilic intensity distribution are generally sweet, pungent, hot and warm. While those with higher electrophilic intensity distribution and highest electrophilic intensity distribution are often b更多还原