【作者】 舒占钧；

【导师】 王魁亮；

【作者基本信息】 新疆医科大学 ， 中医内科， 2004， 硕士

【摘要】 目的:观察保元活血泄浊法治疗早期糖尿病肾病(DN)的临床效果,并探讨治疗本病的机理。方法:将40名患者随机分为4组,每组10人,在基础治疗的条件下,第1组(空白组)只采取基础治疗。第2组(保元抵当汤组)只口服保元抵当汤。第3组(开博通组)予以开博通12. 5mg,每日三次。第4组(开博通保元抵当汤联合组)服用保元抵当汤,分两次服用,同时服用开博通12. 5mg,每同三次。一月为一个疗程。结果:1) 第1组(空白组)在单纯降糖、降压的基础上,有30%可以自行缓解;2组(保元抵当汤组)总有效率达70%,其中显效率为30%。3组(开博通组)治疗DN的总有效率达70%,其中显效率达20%;4组(开博通保元抵当汤联合组)总有效率达80%,其中显效率为60%,保元抵当汤组的显效率明显高于开博通组(P<0. 05) ,但总有效率相同。2) 开博通组、开博通保元抵当汤联合组、保元抵当汤组均不同程度降低DN早期尿微量蛋白的排泄率。析因试验方差结果显示中药保元抵当汤组、开博通组均有统计学差异,但保元抵当汤组在降低DN早期尿微量蛋白上优于开博通组。二者无交互作用。3) 四组在基础治疗的基础上,开博通和保元抵当汤对血糖无影响。4) 四组治疗后,在降低血浆内皮素上,开博通组有统计学差异(P<0. 05) ,而保元抵当汤组无统计学差异(P>0. 05) ,二者有交互作用。结论:1) 保元抵当汤和开博通均可有效地降低DN早期尿微量蛋白。2) 开博通和中药保元抵当汤对血糖无影响。3) 在降低血浆内皮素上,开博通有统计学差异,而保元抵当汤无统计学差异,二者有交互作用。更多还原

【Abstract】 Object: To observe the therapeutic effect of method of protecting Yuan-qi combining with removing blood stasis and resolving turbidity on early stage of DN. Meanwhile to study the possible mechanisms. Methods: 40 patients enrolled were randomly divided into 4 groups. Every group has 10 cases. The group 1 was control group, and group 2 was treated orally with Bao yuan di dang decoction only. The group 3 was treated orally with captopril (37.5mg/d), and group 4 orally was treated with captopril and Bao yuan di dang decoction. The symptoms, blood sugar, urinary albumin and ET were compared after 1 month. Results: l)The total clinical effective rate was30%in group 1, 70 % in group 2, 70 % in group 3 and 80% in group 4 with significant differences (p< 0.01). 2)Bao yuan di dang decoction and captopril were significant factors in the efficacy of reduction in the urinary albumin (p<0.05), but Bao yuan di dang decoction was better than captopril. Meanwhile there were not mutual effects between them. 3)There were no significant differences between captopril and Chinese medicine in the efficacy of reduction of blood glucose. 4)In our trial, captopril reduced the amount of ET as a significant factors, however, Bao yuan di dang decoction was not significant factors. Conclusion: 1)Bao yuan di dang decoction and aptopril could reduce the excretion of the urinary albumin. 2)Bao yuan di dang decoction and aptopril have not valid effects of reducing blood glucose. 3)In our trial, captopril reduced the amount of ET as a significant factors, however, Bao yuan di dang decoction was not significant factors.更多还原