【作者】 李庆；

【导师】 程丑夫；

【作者基本信息】 湖南中医学院 ， 中医内科学， 2004， 硕士

【摘要】 目的：观察益气通脉、清热化痰法及其组方冠心康汤剂治疗冠心病心绞痛(气虚痰热证)的临床疗效并探讨其对炎性因子C-反应蛋白(CRP)、白介素-6(IL-6)的影响。 方法：将60例患者随机分为二组，即冠心康汤剂治疗组与补心气口服液对照组，每组30例，每组以4周为一疗程，并随访3个月，对其疗效进行比较。 结果 1．治疗后二组心绞痛再发次数、持续时间、硝酸甘油服用量、中医证候、心电图、血液流变学、心功能、血脂、CRP、IL-6等观察项目较治疗前均有明显改善(P＜0.01)。 2．治疗后冠心康治疗组各项疗效明显优于补心气口服液对照组(P＜0.05)。 3．追访冠心康治疗组各项疗效较治疗前明显改善，(P＜0.05)补心气口服液对照组各项疗效较治疗前无明显改善(P＞0.05)。 4．追访冠心康治疗组各项疗效明显优于补心气口服液对照组(P＜0.05)。 结论：益气通脉、清热化痰法及其组方冠心康对冠心病心绞痛(气虚痰热证)具有良好的防治作用，且可能对冠心病的炎症机制有干预作用。更多还原

【Abstract】 Objective: To observe the clinical efficacy of supplement qi to invigorate pulse-beat, clear heat to resolve phlegm and their compounded formula Guan Xin Kang on treating Coronary heart disease with angina pectoris(Syndromes of qi deficiency and phlegm heat) ,explore their effects on CRP. IL-6.Methods: Sixty patients were randcmly divided into two groups: Guan Xin Kang treated group and Buxinqi oral liquids control group, each of them has 30 cases of patients. The therapeutic course was four weeks,and followed up 3 monthes. Compared the therapeutic effects of tow groups.Results: 1. After treatment, the observal items such as happen times of angina pectoris , lasting time, the dosage of nitroglycerin, syndromes of Chinese medicine,electroncardiogram, hemorrheology,cardiac function,blood lipid, CRP, IL-6,etc, had been obviously improved(p<0.01).2. After treatment, the efficacy of treatment in the treated group was obviously superior to that in the controll group. (P<0.05).3. the efficacy of treatment in the treated group has obvious improvement before treatment.(p<0.05),while that in the controll group has no evident improvement in the follow up (P<0.05).4. The efficacy of treatment in the treated group was obviously superior to that in the controll group in the follow up (P<0.05).Conclusion: The method of supplement qi to invigorate pulse-beat, clear heat to resolve phlegm and their compounded formula Guan Xin Kang on prevent and cure Coronary heart disease with angina pectoris (Syndrome of qi deficiency and phlegm heat) have good effects.更多还原