【作者】 翟一飞；

【导师】 颜军；

【作者基本信息】 扬州大学 ， 运动人体科学， 2004， 硕士

【摘要】 心理因素对人体免疫系统的影响逐渐受到人们的重视。中枢神经系统、神经内分泌系统等在应激状态下的异常变化是影响机体免疫功能的主要中介。机体面对应激时，交感神经、HPA轴以及其它神经内分泌系统释放的一些神经递质、激素、以及神经肽等等使免疫功能受到抑制。 经常参加身体锻炼，可以使个体获得良好的心理体验，增加自我满足感，阻止或减轻不良情绪的发生。作为一种有效降低应激反应的应付方式，身体锻炼可以减轻机体对心理应激的反应，增加机体的心理耐受力，从而使免疫功能得到了保护。然而，对此机制的研究，目前还不多见。本文试图利用免疫学和神经内分泌学的手段，通过对大鼠β-EP，IL-1β、IL-2和皮质酮的检测来探讨这种有益身心作用的可能机制。 将56只健康雄性SD大鼠随机分为7组，即对照组、电击组、心理应激组、30min运动组、应激+30min运动组、60min运动组、应激+60min运动组。进行8周游泳运动，并在后2个星期施加心理应激。 结果发现：(1)心理应激对大鼠免疫功能的抑制有十分显著的作用。血清IL-1β、IL-2水平显著低于对照组。而皮质酮、β-EP的含量明显高于对照组。(2)运动作为一种降低心理应激的手段对机体的保护作用十分明显。与应激组相比，运动+应激组IL-1β、IL-2水平升高，且β-EP和皮质酮含量均有所下降。 结论：心理应激作为一种应激源，引起大鼠较强的心理反应，从而使机体内分泌功能紊乱并抑制了免疫功能。中等负荷运动在应激状态下对大鼠机体功能的保护非常显著，比小负荷运动更能提高机体的抗应激能力。更多还原

【Abstract】 The influence of mental stress factor on body’s immunity system is becoming more and more important. The abnormal change of central nervous system and neuroendosecretory system are main intermediaries, which can affect the body’s immunity.Physical exercise can bring benefit to people, enhance one’s self-esteenu self-concept, and prevent or relieve the bad emotion and so on. As a effective coping way of bringing down mental stress, physical exercise can decrease intensity of mental stress and increase mental tolerance, so it protects the body’s immunity, but why and what does it work. It is not clear. The thesis instead to explore the possible mechanism from psychoneuroimmunological perspective by measuring the concentration of 3 -EP, CS, IL-1 3 and IL-2 in plasma.Result:(1) Mental stress can depress the rat’s immunity. IL-1 3 and IL-2 in plasma are significantly lower than those in control group. 3 -EP and CS level are significantly higher than those of control.(2)Low and medium exercise, as a effective way of bringing down the mental stress reaction, can protect body health. The IL-1 3 , IL-2 level of exercise +stress groups are higher than those in stress groups. Both corticosterone and 3 -EP are decrease from stress level.Conclusion: Mental stress can make some bad influence on body’s endocrine function and depress the immunity. Low and medium exercise can bring down the stress reaction and protect the neuroendocrine function under mental stress.更多还原