【作者】 张建平；

【导师】 赵林；

【作者基本信息】 天津大学 ， 化学工程， 2004， 硕士

【摘要】 近年来有关水分子簇结构与功能的研究已经成为当今科学前沿的热点之一，针对它的进一步研究可望为深层次揭示化学、化工传质和生命科学等领域的本质问题提供有利工具。本文较为全面地概述了十几年来关于水分子簇理论及实验研究的发展状况，归纳出4种改变水分子簇内部结构的方法，包括外加电场、外加磁场、激光辐射和直接加热法，并对其改变水分子簇结构的作用原理进行了阐述。针对当前各类化工传质及药物释放过程中水所担当的重要角色，从微观角度入手，研究因为水分子簇结构的变化而对化工传质及药物释放产生的影响。首先通过磁场、远红外等外加作用，改变水分子簇结构，并通过比较其红外光谱、电导率、粘度、表面张力等物化性质的变化来验证其团簇结构的变化。其次，选取由乙酸、水和四氯化碳组成的萃取体系，用分子簇结构发生变化的水作萃取剂，从四氯化碳中萃取溶解的乙酸。结果表明水在经过上述作用后其溶解、扩散能力有了显著增强。第三，以水杨酸为模型药物研究分子簇结构发生变化的水对药物释放过程的影响。在实验中发现药物总的释放量和释放速率都有不同程度的提高。第四，针对药物释放过程建立理论模型，并将由实验数据拟和的动力学方程与理论模型相比较，各动力学方程与模型方程相吻合。更多还原

【Abstract】 The structures and functions of water clusters have been one of the hottest points in modern science recently. It may be a very favorable method to deeply uncover the natures of questions in the fields such as chemistry, chenmical mass transfer and life sciences.In this paper, we describe the general situation of study and investigation on water cluster in decade years firstly,and outline four methods in changing the structure of water clusters, including external electric field, external magnetic field, laser radiation and heating methods．The mechanism of these four methods are also explained in detail．Because of the important roles of water in chemical mass transfer and drug release.We set out to investigate the effections of structural changed water clusters on mass transfer and drug release.First, the structure of water clusters are affected by external magnetic field and far infrared ray, and the structural changes are certified through its infrared spectrum, electric conductivity, viscosity and surface tension.Second, the extraction system composed of acetic acid, water and carbon tetrachloride is selected. Acetic acid is extracted from carbon tetrachloride by structural changed water as extractant, and the dissolve and diffuse abilities are remarkably enhanced as a result.Third, salicylic acid is selected as a model drug to disguss the effections of structural changed water clusters on drug release, and it is discovered during the experiments that the total release amount and release velocity are improved to different degrees.Fourth, a theoretical model about drug release is set up, and the kinetics equations derived from experimental data are in good <WP=5>accordance with model equations.更多还原