【作者】 戚玉敏；

【导师】 崔春翔；

【作者基本信息】 河北工业大学 ， 材料学， 2004， 硕士

【摘要】 目前表面改性已成为钛基生物医学材料研究的一个重要方向，其目的是提高材料在生体环境中的生物相容性和生物活性。由于材料的表面形态直接影响了植入材料的生物相容性和种植效果，而生物活性能提高材料的骨键合能力，因此材料形态学表面改性技术和表面生物活化的研究将为生物医学材料的发展提供良好的应用前景。本研究结合了形态学表面改性和化学处理两种方法制备了具有生物活性的表面微孔钛／钛基生物医学材料，并对材料的制备工艺及其生物学性能进行了系统研究。 以廉价的K₂CO₃和TiO₂为原料，用改进的烧结法反应合成钛酸钾晶须，利用SEM、XRD分析了不同原料配比和反应温度及时间对晶须形态、尺寸和相组成的影响，确定了优化的合成工艺，即K／T=1：3～4，900℃×1h合成四钛酸钾晶须；K／T=1：5～6，1000℃×1h合成六钛酸钾晶须。利用TEM对晶须的微结构进行分析和表征。结果表明，晶须的结晶度和外观质量好，收率高。 表面微孔钛的制备采用了独特的工艺方法，即利用钛酸钾晶须包埋纯钛短时间煅烧而后快冷处理后钛独特的氧化分层现象，制备出表面微孔钛，所制得的微孔形态多样，但在基体表面分布均匀，表面粗糙度在5um左右，明显不同于其他形态学表面改性方法获得的微孔形貌。然后采用低温碱浴处理在微孔表面均匀地形成了一层多孔网状的二氧化钛凝胶层，在生体环境中可自发诱导形成呈梯度分布的骨样磷灰石，表现出很好的生物活性。 通过耐蚀性试验、模拟体液培养、体外细胞培养实验对碱浴处理后的表面微孔钛／钛基生物医学材料的耐蚀性、生物相容性和生物活性进行了评价。结果表明：碱浴处理后表面微孔钛／钛基生物医学材料具有很高的耐蚀性、生物活性和生物相容性。更多还原

【Abstract】 At present, the surface modification has become a main research field of Ti matrix biomedical materials. The aim of the surface modification is to improve the biocompatibility and bioactivity in the body environment. Because the surface configuration indirectly affects the biocompatibility and implanting effect of the implants, and bioactivity can improve the osteointegration of materials, the studys on morphological surface modification technology and surface bioactivation will offer a delightful application prospect for the development of biomaterials. In the study, bioactived surface micro-porous titanium/Ti matrix biomaterial was prepared by combining morphological surface modification technology with chemical treatment way, fabrication techniques and biomedical characteristics of the material were also systematically investigated.Low cost K2CO3 and TiO2 were used as raw materials to fabricate potassium titanate whiskers by reaction sintering method ameliorated . By SEM and XRD, the effects of K2CO3 and TiO2 ratio and reaction temperature and time on configuration, size and phase components of the whiskers were analyzed in this paper. In the end, the optimal fabrication techniques was confirmed, that is potassium tetratitanate whiskers prepared with K/T=1:3~4 and 900℃xlh and potassium hexatitanate whiskers prepared with K/T=1:5~6 and 1000℃ x 1h. TEM was used to analyze the microstructure, the result indicated that the high quality potassium titanate whiskers with good crystallinity and high output were gained.The surface of titanium matrix was modified with micro-pores by adopting special craft, which the pure titanium cladded with potassium titanate whiskers was calcined for a short time, then rapidly cooled , the surface micro-porous titanium was prepared by the special oxidizing delamination of the titanium. Micro-porous are various, which is obviously different from those morphologies gained by the other morphological surface modification technologies , and even distributing on the surface of Ti matrix, The surface roughness degree is about Sum. Titanium oxide was formed on the surface of micro-porous titanium after alkali treatment at low temperature. The networks of titanium oxide induced the deposition of hydroxyapatite in the body environment; this showed that bioactived micro-porous surfacehad good bioactivity.The corrosion resistance property, biocompatibility and bioactivity of the bioactive surface micro-porous titanium/Ti matrix biomaterial were evaluated by corrosion, the simulated body fluid cultivation and cell cultivation experiments. The results showed that the bioactived surface micro-porous titanium/Ti matrix biomaterial possessed superior corrosion resistance property, biocompatibility and bioactivity.更多还原