【作者】 杨硕；

【导师】 徐桂芝；

【作者基本信息】 河北工业大学 ， 电工理论与新技术， 2004， 硕士

【摘要】 脑是人体的最高神经中枢，控制着人体的各个组织器官。脑疾病时刻困扰着人类，已经成为人类伤残和死亡的主要原因之一。早期的诊断、及时的治疗成为减少伤残、死亡的关键。 颅内组织电特性主要参数是颅内组织电阻抗。通过在头皮表面安置大量电极，注入低频安全激励电流信号，同时测量头皮边界的电位，根据在头皮表面测得的电位的变化可以推测颅内组织电阻抗的变化情况。不同组织具有不同的电阻抗，异变组织电阻抗也不同于正常组织的电阻抗，因此可以由颅内组织电阻抗的变化推知颅内组织异变的情况。这种监测方法具有无创、实时、成本低廉的优点，因此本文就颅内组织异变对头皮边界节点电位的影响做了系统的研究。 主要内容如下： 1．开发了真实头模型和完全头模型两种情况下的有限元分析软件。该软件可以给出各种异变情况下头皮边界节点电位值，绘制头皮边界节点电位相对变化曲线。 2．对二维真实头模型，分析了大脑组织在异变的种类、大小、位置不同时头皮边界节点电位分布情况。结果表明颅内组织异变对头皮边界节点电位的影响明显。 3．对二维完全头模型，通过比较真实头模型和完全头模型头皮边界节点电位，分析了头皮—电极接触阻抗对头皮边界节点电位的影响，以及当组织异变时头皮—电极接触阻抗对头皮边界节点电位的影响。更多还原

【Abstract】 The brain is the nerve center of human being and controls the tissues and apparatus in the body. People are puzzled by brain diseases frequently. Brain diseases are the chief factors to human health. So the earlier diagnose, therapy in time is very useful.Encephalic tissues impedance is the main parameter of encephalic tissues electrical characteristics. Currents are injected into brain through electrodes placed on the scalp, and the resulting electrode voltages are measured. From the voltages, the encephalic tissues impedance can be estimated, and then we can know something about the brain disease. It has some strong points, such as non-invasive, real time and convenience. So in this paper, we study the effect of encephalic pathological tissues on scalp boundary nodes potential.The main research work is as following:1. The software package of real head model and complete head model has been developed. This soft ware can be used to calculate the scalp boundary nodes potential in many kinds of brain diseases and plot the scalp boundary nodes potential relative changes curve.2. For 2D real head model, the scalp boundary nodes potential distribution has been studied when the encephalic pathological tissue changes its kind, area or position. The result shows the encephalic pathological tissues have effect on the scalp boundary nodes potential.3. For 2D complete head model, the effect of scalp-electrode contact impedance on scalp boundary nodes potential has been researched through the compare of the scalp boundary nodes potential in real head model and complete head model. And the effect of scalp-electrode contact impedance has also been studied when the tissues have pathological changes.更多还原