【作者】 李冬梅；

【导师】 唐强；

【作者基本信息】 黑龙江中医药大学 ， 针灸推拿学， 2003， 硕士

【摘要】 目的：进一步阐述头穴丛刺对急性脑梗死的作用机制。方法：运用血管内栓线法制备雄性wistar大鼠局灶性脑缺血的动物模型，模拟人类急性脑缺血损伤的病理变化，以神经功能评分，平衡木、转棒、网屏测试、病理形态学，细胞凋亡为指标，进行了术后24h、5d、10d后，各组间及组内的对比观察。结果：(1)头穴丛刺治疗能明显提高脑缺血大鼠抓握、平衡、行走能力，及增加患肢肌力；(2)促进脑缺血周边区胶质细胞及胶原纤维增生，减轻组织水肿程度，减少梗死灶体积；(3)抑制脑缺血，减少缺血半暗区脑细胞凋亡数目，减轻缺血损伤。结论：头穴丛刺能减少脑缺血性损伤所造成的细胞死亡或凋亡，对神经元具有保护作用，因而能提高神经功能，为该治疗方法在临床应用中提供了理论依据。更多还原

【Abstract】 In this subject,the male rats of Wistar strain were selected as experimental study objects.40 rats were divided into four groups by random: false operation group(group A),model group(group B),Baihui to Qubin group(group C),cluster needling of scalp point group(D).To anologue the pathologic change coursed by cerebral ischemia in human,the animal model were made by blocking middle cerebral artery.Neuronal function evaluation, halter test,rotation test, reticular screen test,pathomorphologic charge,and cell apoptosis were selected as indexes. We contrasted the difference among different groups at 24 hours, 5 days and 10 days after the operation and tried to show the mechanism of cluster needling of scalp point therapy in acute cerebral infarction from the scopes of bebavior medicine pathomorphology.The study showed that cluster needling of scalp point therapy can improve cerebral infarct rat’s grasping equilibrating, moving functiom and strengthen myodynamia;improve glia cell and collagenons fibers hyperplasia and reduce cerebral tissue edema and infarct volume.Restrain cell apoptosis and lighten the injure of infarction.The study proved that the therapy of cluster needling of scalp point can reduce ischemic cell damage and delay programed cell death or apoptosis after cerebral infarction. It can protect and repair neuron.This experiment provided theoretical basis to clinic.更多还原