活血化瘀汤对冠心病急性心肌缺血内皮功能保护作用的实验研究

【作者】 杨莺；

【导师】 杨积武；

【作者基本信息】 辽宁中医学院 ， 中西医结合临床， 2003， 硕士

【摘要】 目的：观察中药活血化瘀汤对冠心病急性心肌缺血内皮功能的保护作用。 方法：实验动物随机分为5组，通过结扎麻醉兔的冠状动脉左前降支中段，造成急性心肌缺血模型，采用比色法测定NO、NOS，放射免疫法测定ET。 结果：急性心肌缺血时，血浆NO、NOS水平下降，ET明显升高，中药活血化瘀汤可以提高血浆NO、NOS浓度，降低ET水平。 结论：中药活血化瘀汤有提高血浆NO、NOS，拮抗ET的作用，调节NO／ET释放平衡，改善心肌缺血，保护血管内皮细胞，从而达到防治冠心病的作用。更多还原

【Abstract】 Objective:Observations on protective of Huoxue huayu decoction on function of endothelial cells in acute mycocardial ischemic of coronary heart disease. Methods:The rabbits were randomly divided into five groups ,the animal model of acute myocardial isehemia was reproduced in anesthetited rabbit by ligating the left coronary artery at the middle of anterior descending branch. The serum NO, NOS and plasma ET were determined by colorimetry and radioimmunoassecy respectively. Results:As the time of occulusion extended , the serum NO, NOS gradually decreased and the plasma level of ET elecated. Significantly, the decoction for HXHY can increase the level of NO, NOS and decrease the level of ET. Conelusion: The decoction for HXHY can incease the level of NO, NOS and reduce the level of ET in acute myocardial ischemia of rabbits, impel the balance of NO/ET, perfect myocardial ischemia, protect endothelial cells ,thus prevent and cure coronary heart disease.更多还原