【作者】 徐彦军；

【导师】 覃兆海；

【作者基本信息】 中国农业大学 ， 农药学， 2003， 硕士

【摘要】 化合物ZNQ-06是本研究小组前期工作中发现的一个具有较好除草活性的化合物，为了进一步确认其活性，本文对其杀草谱和有效作用剂量进行了进一步的研究，结果表明，在1.5kg／ha的剂量下，该化合物对马唐、反枝苋、紫苋菜等有较好的防除效果。同时根据实验现象，我们推测该化合物可能具有与原卟啉原氧化酶抑制剂二芳醚类除草剂类似的作用机理，因此，我们以该化合物作为先导，对其结构进行了进一步的改造，在吡啶环上引入二芳醚类除草剂的典型结构单元—芳醚，设计并合成了10个具有如下结构的新化合物：其结构经元素分析、~1H．NMR确证。 对合成化合物的初步除草活性测定表明，在浓度1000mg/L以下，这些化合物仅表现出微弱的除草活性，远低于先导化合物ZNQ-06，说明吡啶环2-位上的氯原子可能对维持化合物除草活性是必需的，但这一结论还有待进一步的实验来证实。更多还原

【Abstract】 Further biological evaluation had been carried out on ZNQ-06, a herbicidal leading compound which was found in previous work of our research group. At a dose of 1.5kg/ha, it exhibited a broader herbicidal spectrum and good inhibiting rates and the results showed that it might act on weeds in a similar model to that of protoporphyrinogen oxidase-inhibiting herbicides.In order to improve the herbicidal activity of the leading compound, a typical moiety of protoporphyrinogen oxidase-inhibiting agents, aryl ether, was introduced to the sketch and a new series of compound were synthesized.The structures were confirmed by 1H NMR and elementary analysis.Preliminary herbicidal evaluations showed that all the synthesized compounds just give a poor inhibiting rate at 1000mg/L and much weaker than ZNQ-06 itself. The result suggests that chloro atom on 2 position of thiodiazole ring might be necessary to herbicidal activity.更多还原