【作者】 沈桂平；

【导师】 谢树森； 李晖；

【作者基本信息】 福建师范大学 ， 光学， 2003， 硕士

【摘要】 本论文从激光和生物组织的光热作用物理机理出发，开展激光与鼻咽组织光热响应的理论与实验研究，为诊断/定位肿瘤时选择光剂量和确定组织温度分布提供理论和实验依据。首先利用MC模型和生物传热的理论模型Pennes方程对生物组织中的光传输特性和温度分布的无损重构进行模拟研究；其次设计Ar~+激光(波长：488nm、514.5nm)辐照“活性蛋白”组织模型和几种哺乳动物组织(离体猪肌肉组织、鼻咽组织)诱发温度分布的实验测量方案，研究激光波长、能量密度和辐照时间对生物组织温度分布的影响；理论和实验结果表明：组织中的温度分布与组织不同深部位置、激光波长以及激光辐照能量密度有关；实验获得波长488nm和514.5nm的Ar~+激光分别辐照鼻咽组织时安全光剂量分别为1.85W/cm~2和1.72W/cm~2的重要数据，相关的成果可为鼻咽癌的光动力学诊断提供若干理论结果和有用的实验数据。更多还原

【Abstract】 Based on the physical mechanism of optical-thermal response of biotissue during laser irradiation, the dose of laser and the distribution of the temperature field of nasopharyngeal tissue were studied in this thesis. This can provide theoretic and experiment foundation for choosing the light dose and obtaining the temperature distribution in tissue during diagnosing and localization of tumor.Firstly, the transfers characteristic of laser and the temperature distribution in the nasopharynx tissue induced under the irradiation of laser were simulated by the Monte Carlo model and ID Pennes’ bioheat transfer equation respectively.Secondly, the experiment project presented in this thesis offer a measurement to detect the temperature distribution in the albumen phantom in vivo and several mammalian tissues such as porcine nasopharynx tissue in vitro. The changing of temperature was induced under the irradiation of argon ion laser emitting at the wavelength of 488nm and 514.5nm, respectively. Furthermore, the dependence of measuring position, irradiation time and irradiation energy density, as well as wavelength on the temperature distribution was studied in detail.Simulation results and experimental results show that the temperature distributions in the porcine nasopharynx tissue were significantly affected by measuring position and the energy density and wavelength of irradiation laser. The experiment results show that safe dose of porcine nasopharynx tissue during the irradiation of argon ion laser at the wavelength of 488nm and 514.5nm is 1.85W/cm2 and 1.72 W/cm2 .respectively.The results obtained of this thesis can contribute to further investigation and several theories foundation and useful experiment data in the optothermal biotissue response during laser irradiation and clinical laser applications such as laser dynamically diagnosing nasopharyngeal carcinoma.更多还原