【作者】 张涛；

【导师】 陈晓品；

【作者基本信息】 重庆医科大学 ， 肿瘤学， 2002， 硕士

【摘要】 目的：分析138例乳腺癌临床病理特性的预后价值。方法：收集自1996年5月1日至1997年12月31日我科收治的经病理证实的138例乳腺癌患者的病史资料，分析年龄、肿瘤大小、肿瘤组织学分级、激素受体状态、腋窝淋巴结转移情况及绝经情况对乳腺癌预后的影响。结果：本组乳腺癌病例5年总体生存率为74.84％（自然寿命表法）。据SAS6.12软件Pro Logistic 回归分析患者5年总体生存率与肿瘤大小、肿瘤组织学分级、腋窝淋巴结转移及ER均显著相关。而与PR、绝经情况和年龄无明显关系；患者5年远地转移发生率与腋窝淋巴结转移显著相关，而与肿瘤大小、组织学分级、ER、PR、年龄及绝经情况无关；5年局部复发率与本组资料所研究的因素均无关 。结论：肿瘤大小、肿瘤组织学分级、ER及腋窝淋巴结转移情况对乳腺癌是有价值的独立的预后因素。没有证据证明年龄及绝经情况是有意义的预后因素。更多还原

【Abstract】 Objective:To investigate the value of clinical prognostic fators in 138 patients with breast cancer .Methods:The analysis was performed in 138 cases of the breast cancer treated from May 1 ,1996 to Dec 31,1997.The correlation of age, tumor size, histologic grade of the tumors, axillary lymph node involvement, oestrogen receptor status, progesterone receptor status, menopause status with prognosis of breast cancer was evaluated.Result:The5-year overall survival rate was 74.84 % in this group using nature lifetable analysis. Pro Logistic analysis revealed that 5-year overall survival rate of this group was significantly associated with tumor size, histologic grade of the tumors, axillary lymph node involvement, oestrogen receptor status. And progesterone receptor status, age, menopause status had no significant independent prognostic value. In addition, the rate of 5-year distant metastases in this group was associated with axillary lymph node involvement. But it was not any association with tumor size, histologic grade, progesterone receptor, oestrogen receptor, age and menopause status. It also<WP=7>was not demonstrated that any factors had significant association with the 5-year local recurrent rate. Conclusion:Our data demonstrated that tumor size, histologic grade, oestrogen receptor status and axillary lymph node involvement were significant independent indicators of prognosis in breast cancer respectively，and it was not demonstrated that age and menopause status were significant prognostic factors.更多还原