事件相关fMRI及其数据处理

【作者】 俞兵；

【导师】 李福利；

【作者基本信息】 首都师范大学 ， 光学， 2002， 硕士

【摘要】 近一二十年发展起来的功能核磁共振成像技术使得在无损伤的情况下能够研究正常人大脑内部工作的实况，提供人脑结构和功能方面的信息。而事件相关核磁共振成像的出现则是一次变革性的进步，为人类研究脑的高级功能提供了新的有效方法。事件相关核磁共振成像及其数据处理是本论文的研究的主要内容。 本论文的重点是： (1) 阐述事件相关核磁共振成像的特点，事件相关设计与传统的组块设计相比的优势。 (2) 详细分析用反卷积对事件相关核磁共振成像时间序列数据进行处理的理论。 (3) 通过人类手指简单、复杂运动的脑功能成像研究的实例来说明事件相关设计的优点。该实验的设计基于事件相关设计，数据处理用反卷积的方法。 论文共分四章，其中引言主要对脑功能研究的意义，功能核磁共振成像技术研究脑功能的可行性及事件相关核磁共振成像的特点作了概述。 第一章对用功能核磁共振成像技术进行脑功能研究的理论基础和可行性进行了论述。并对脑功能研究的实验方法以及实验设计过程中应该注意的事项进行了总结。 第二章详述了事件相关核磁共振成像及其特点。 第三章是用反卷积分析事件相关fMRI时间序列数据的理论部分。其中运用了线性系统，线性回归、统计学的部分理论。 第四章是人类手指简单、复杂运动的脑功能成像研究。这是事件相关fMRI的一实例应用。实验实现了随机化的任务刺激，用反卷积的方法分离四种复杂度手指运动的脑功能激活区，并进行比较。实验的初步结果说明了事件相关设计的优点。更多还原

【Abstract】 The technology of the functional magnetic resonance,developed in the near twenty years,enables people to study,without any damage,how normal people’s brains actually work and provides with more information about the structure and function of human being’s brain. The occurrence of event related fMRI is a revolutionary progress. It provides us a new effective method of studying advanced function of human brain. .The main content of this thesis is event related fMRI and its data processing.The emphasises of this thesis are as follows:(1) Detail with the characteristics of event related fMRI and the predominance of event related design compares to block design.(2) Expound the theory of using deconvolution analyzing time series datas of event related fMRI.(3) Illustrate the predominance of event related design with a study on the simple and complex finger tapping for motor activation. The experiment design is based on event related design. The method of its data process is deconvolution.This thesis is composed of four chapters,except the introduction which gives a brief introduction to the significance of studying brain’s functions,the characteristics of the event related fMRI,as well as the feasibility of using fMRI to study the brain’s functions.Chapter One discusses the theoretical base and feasibility of using fMRI to study the brain’s functions,and concludes the study methods and the points for attention in the experiment procedure.Chapter Two details with event related fMRI and its characteristics.Chapter Three is the theoretical part of using deconvolution analyzing time series datas of event related fMRI. It makes use of part theories of lineal system,lineal regression and statistics.Chapter Four is a study on the simple and complex finger tapping for motor activation. This is a application of event related fMRI. It realizes the randomization of input task stimulus. It separates motor brain activations of four different tasks of finger tapping and gives a contrast. The elementary results in this experiment illustrates the merits of event related design.更多还原