【作者】 旺建伟；

【导师】 李冀；

【作者基本信息】 黑龙江中医药大学 ， 方剂学， 2001， 硕士

【摘要】 头风病是临床常见病，相当于现代医学的偏头痛。据流行病学调查，该病的患病率已达985.2/10万，并有逐年增长趋势，已严重影响人们的健康和生活质量。现代医学对偏头痛的研究已取得不断的进展，但由于对其发病机制的认识尚未完全清楚，故对偏头痛的治疗处于部分有效阶段。故此，立足于中医药理论基础，以辨证分型为主，对其配伍遣药组方法则进行深入系统研究，具有较为广阔的前景。 本课题旨在通过动物实验，进行拆方配伍研究，以方剂学的角度，探讨阐明疏解少阳法与祛风止痛法治疗头风病的内在配伍关系及规律，为临床及深入研究组方配伍法则做奠定性的基础。 祖国医学文献研究表明，头风病病因病机与风、痰、瘀、火、虚等有关，其中与风、痰、瘀关系密切；病位多在少阳、厥阴经；脏腑多与肝、胆有关。现代医学文献研究表明，偏头痛的发病机制为多元化，其中与5—HT含量变化、血小板聚集功能改变等关系密切。 动物实验研究旨在通过拆方配伍研究以探求疏解少阳法、祛风止痛法治疗头风病的组方用药规律，并阐明疏解少阳法、祛风止痛法治疗头风病的内在配伍关系及其治疗机理。实验表明全方具有镇痛、镇静作用，能增高小鼠大脑5—HT含量，降低体外血栓形成的长度、湿重、干重，并能降低ADP诱导的血小板聚集率。在各项实验指标中，各拆方具有不同程度的作用，全方则具有显著或明显的作用。结果表明，全方高量组的疗效最为显著，全方低量组次之，与阳性对照组相近。疏解少阳组和祛风止痛组在不同的实验中疗效不一。由此可见各拆方的作用与全方所产生的药效作用绝非简单相加的关系，而是由中药方剂的内在配伍规律作用所致。因此，有关配伍关系，应进行更深入的研究与探讨。更多还原

【Abstract】 ou Feng?is one kind of disease common disease, and belongs to Migraine and Vascular Headache in the field of modern medicine. According the epidemi?ological survey, the sickness rate of the diaease is about 985. 2/lOs , and the rate is rising up graduatly.Therefore,based on diagnosis and treatment of fundamental knowledge of TCM.There exists broad prospect by systemly studying compatibility of medicines in the prescription.The subject aims at studying compatibility of medicines in the prescription to explicating the rationality of the prescription according to the therapeutic methods of treating shaoyang disease by dispersing and dispee]ing wind and relieving pain.The research of TCM documents shows that the pathogenesis of 揟ou Feng?is related with wind, phlegm, blood stasis, fire and deficiency, mostly with wind,phlegm and blood stasis, the latibulum is on the shaoyang and the jueyin. The research of west medicine documents shows that the pathogenesis of Migraine is multifactor, mostly is related with the change in the content of 5桯T and aggregation of platelet.The animal experiment manifests that this prescription has analgesia and sedative effection, increases the content of 5桯T in the cerebrum of the mice, inhibits experimental thrombosis and decreases the rate of platelet aggregation induced by ADP. Different therapeutic methods ,when made up4withone another, have particular inner link.更多还原