【作者】 郭欣；

【导师】 朱治忠；

【作者基本信息】 黑龙江中医药大学 ， 中西医结合临床， 2001， 硕士

【摘要】 本课题综述了现代医学对便秘问题研究的概况，从神经病理学及组织化学角度探讨了便秘的病因、发病机理以及治疗方法的最新进展。目的 深入研究便秘的病因、发病机制及外科治疗效果。方法 在临床上经结肠气钡双重造影及排便造影确诊，而内科保守治疗无效的慢性顽固性便秘患者，将病例随机分组，对照组采用常规剂量疗程中药口服，处理组给予左半结肠切除，直肠粘膜结扎注射固定术，术后结肠标本做病理检查。结果 病理检查显示：结肠肌间神经丛有退行性改变，手术治疗组比对照组疗效显著（P＜0.05）。结论 1、慢性顽固性便秘并非功能性疾病，而是器质性疾病。2、治疗便秘不应再采用接触性泻剂。3、便秘的治疗观念需要更新，采用外科治疗为主的综合治疗是便秘治疗的发展趋势。更多还原

【Abstract】 The paper summarizes the general situation of constipation in Modern Medical Science, explodes the newest development of the cause, the pathogenesis and the treatment of constipation.Objective Studing the affluence of cause, pathogenesis and surgeon methods of constipation.Methods Chosing chronic severe constipation patients in clinic to divide into two groups in random; control group is adopted usual dosage and procedure of Traditional Chinese medicine; surgeon treatment group is adopted left colectomy and rectal mucosa ligation and proctopexy with injection method, sample through pathological examination.Results There is a distinct ultrastructural neuropathology of colonic myenteric plexus, surgeon treatment group has a distinguish effect in comparsion with internal treatment group.Conclusionl~ chronic severe constipation is not a functional disease but a structural disease.2~ Contact laxatives should be prevented to adopt to treat constipation.3.. The idea of constipation treating method should be changed into adopting mainly surgeon methods and other synethesis treating method.更多还原