【作者】 陈泉；

【导师】 吴立军；

【作者基本信息】 沈阳药科大学 ， 药物化学， 2001， 硕士

【摘要】 绍兴市医药工业研究院（即浙江医药股份有限公司新昌制药厂研究院）在对淡竹叶的活性研究中发现，其具有优良的降血脂作用，但该活性部位化学成分不清。为阐明淡竹叶降血脂的物质基础，对淡竹叶降血脂的活性部位进行了化学研究。 经过溶剂萃取法及多次柱色谱法从淡竹叶的活性部位中分离得到了11个化合物，其中8个化合物经波谱分析、与对照品比较及文献对照，确定为：4-羟基-3,5-二甲氧基苯甲醛（4-hydroxy-3,5-dimethoxybenzaldehyde，Ⅰ）、苜蓿素（tricin，Ⅱ）、香豆酸（p-coumaric acid，Ⅲ）、5,4’-二羟基-3’，5’-二甲氧基-7-β-D-葡萄糖氧基黄酮（5,4’-dihydroxy-3’，5’-dimethoxy-7-β-D-glucosyloxy-flavone，Ⅳ）、牡荆素（vitexin，Ⅴ）、胸腺嘧啶（thymine，Ⅵ）、香草酸（vanillic acid，Ⅶ）、腺嘌呤（adenine，Ⅷ）。这8个化合物均为首次从该属植物中分得，其它化合物的结构正在鉴定中。 药理实验表明，淡竹叶提取物具有优良的降血脂作用，能明显降低高脂血症大鼠血清总胆固醇和甘油三酯的水平。更多还原

【Abstract】 ABSTRACT The staff in Shaoxing Institute of Pharmaceutical Industry (namely the Institute of Xinchang Pharmaceutical Factory attached to Zhejiang Medicine Co. Ltd.) found out that Lop hat he rum gracile Brongn. (Gramineae) showed effective pharmacological activity of antiipemic in its active part. But chemical composition in active part is unclear. In order to disclose material base in active part We took chemical constituent study on the antiipemic active part of L. gracik Brongn.. Eleven compounds were isolated from the active part of L. gracile Brongn. through the methods of solvent extraction and re-performed silica gel chromatography. Eight of them were identified by spectral analysis and comparison with standard samples and related references. These eight compounds are as following: 4-hydroxy-3,5-dimethoxybenzaldehyde (I), tricin (II), p-coumaric acid ( LU ) , 5,4 ?-dihydroxy-3 ?,5 / -dimethoxy-7- ~ -D-glucosyloxy-flavone (IV) , vitexin (V) ,thymine(VI), vanillic acid (VII), adenineOjl). The eight compounds were obtained from this genus for the first time. The pharmacological test indicated that the extract of Lophatherum gracile Brongn. possessed effective antilipemic activity. It can obviously lower the levels of serum total cholesterol and triglyceride of hyperlipidemic rats.更多还原