新型抗病毒药物Pleconaril的合成研究

【作者】 赵燕芳；

【导师】 宫平；

【作者基本信息】 沈阳药科大学 ， 药物化学， 2001， 硕士

【摘要】 本论文简述了病毒的结构特点和抗病毒药物的发展概况，详细介绍了新型广谱抗小RNA病毒药物Pleconaril的作用机制，着重研究了Pleconaril的合成。设计并打通了Pleconaril的合成路线，并对其合成工艺进行了较为详尽的考察和改进，使操作简便，收率提高。以2，6-二甲基苯酚为起始原料，包括侧链的制备，共经十步反应得到Pleconaril，反应总收率为37.4％，其结构由红外光谱、核磁共振氢谱、核磁共振碳谱、质谱得以确证。并选择了不同的溶剂，对该品的多晶型进行了研究。更多还原

【Abstract】 The characteristics of virus and the development of antiviral agengts were briefly described in this paper, and the mechanism of a new broad -spectrum Picomavirus Inhibitors-Pleconaril was also introduced. The synthesis of Pleconaril was studied. A new synthetic route was designed and modified, which make easier to process, and the yield was elevated. The total yield of Pleconaril was 37.4%, which was synthesized from 2,6-dimethyl-4-hydroxyphenol by ten steps, including the preparation of side chains. Its structure was confirmed by IR, 1H-NMR, ?C-NMR, MS. The polymorphs of Pleconaril was also studied in different solvents.更多还原