中药与环磷酰胺合用对肾病患儿性腺影响的临床研究

【作者】 刘娟；

【导师】 张亚荣；

【作者基本信息】 山东中医药大学 ， 中医儿科学， 2001， 硕士

【摘要】 环磷酰胺是治疗难治性肾病综合征的常用药物，有关其对性腺的影响，西医已有多篇报道。本文随访观察26例曾用健脾补肾中药和环磷酰胺治疗的肾病患儿，通过生育情况调查、精液检查、性激素测定和第二性征检查，评价中药和环磷酰胺合用对性腺的影响。观察结果显示26例患者性腺发育正常，无一例性腺损伤，提示在使用环磷酰胺同时，健脾补肾中药的较长期应用可能起到一定作用。因各种客观因素存在，本文未能完全证实此结论，仅结合相关资料，分析认为健脾补肾中药可减轻疾病本身对生殖功能影响，并可能通过清除自由基和调节性腺轴而对抗或减轻环磷酰胺的性腺毒性。更多还原

【Abstract】 Cyclophosphamide( CTX) is a usual medicine for treating Refractory Neplirotic Syndome (RNS). There are several reports about the effect of CTX on gonad in western medicine at present. This article observed twenty ? six infantile refractory nephritis who had used CIX and chinese medicine of invigorating speen and kidney. Through investigating their childbearing history, analysinsing sperm, assaing sexual hormones and ex- aznining the second sexual character, we evaluate the effect on gonad by using CIX and chinese medicine meantime The result shows that all of the patients?gonads are normal development . It suggests that chinese medicine of invigorating speen and kidney should exert certain effect as CIX was used meantime. But the conclusion isn?t definite completely for much of objective factor. Through consulting data related, we consider that chinese medicine can decrese the effect of RNS. At the same time, it possibly could avoid or decrease the harm of CIX on gonad from two directions which are clearing free radical and adjusting gonad axis.更多还原