左金丸及其生物碱相关药效对比实验研究

【作者】 熊平；

【导师】 许利平； 文昌凡；

【作者基本信息】 成都中医药大学 ， 中药学， 2001， 硕士

【摘要】 目的：比较左金丸生物碱、水煎剂、散剂的有关药效作用，证明左金丸生物碱是其药效作用的主要活性部位，为进一步研制新制剂提供实验依据。方法：以镇痛、抗溃疡、调节胃肠功能等为主要药效观测指标，观察左金丸生物碱与水煎剂、散剂的药效作用。结果：左金丸散剂、水煎剂及生物碱在不同程度上都有保护胃粘膜、抗溃疡、镇痛、抑制小肠推进运动和胃液分泌、对抗乙酰胆碱和组织胺的作用。左金丸散剂保护胃粘膜、抗溃疡作用优于左金丸生物碱，水煎液抗溃疡和抑制胃液分泌作用弱于左金丸生物碱；左金丸水煎液镇痛作用优于生物碱，散剂弱于生物碱；左金丸水煎液抑制小肠推进运动作用弱于生物碱和散剂；左金丸水煎液和生物碱对抗组织胺和乙酰胆碱作用优于散剂。结论：初步推断左金丸生物碱是左金丸镇痛、保护胃粘膜、抗溃疡、抑制小肠推进运动和胃液分泌的主要活性部位。更多还原

【Abstract】 OBJECflVE: To compare the pharmacological effects of ZuolrnWan alkaloid and ZJW in the dosage of decoctron and powder on its related effects in onier to pinve that the alkaloid is the main effective paxt of ZJW, aiming at pwviding experimental data for devel- oping advanced dosage. METHODS: By means of the pain - relieving, anti - ulcer, re- fntining the secretion of gastric fluid and adjust the function of stomach and intestine in- dexes as the main effective ones, the phannacological effects of ZJW in the dosage of pow- der and decoction and its alkaloid are observed. RFSULTS: ZJW in the dosage of powder and decoction and its alkaloid have the following functions: pmtecting gastric mucosa, anti ?ulcer, relieving pain, and refraining the movement and secretion of small intestine and gastric fluid respectively to the different degree. ZJW powder is prior to its alkaloid in anti ?ulcer respect, while its decoction is infenor to the alkaloid in anti - ulcer and refraining secretion of gastric fkud. As for relieving pain, the decoction is better than the alkaloid, and the powder is weaker than the alkaloid. As for refraining the movement of small intes- tine, ZJW deooctron is weaker than its powder and alkaloid. As for counteracting histamine and acetylcholine, ZJW decoction and alkaloid are better than its powder. CONCLU- lION: It is inferred ZJW alkaloid is the main effective part in its relevant pharmacology更多还原