【作者】 莫文军；

【导师】 周长忍；

【作者基本信息】 暨南大学 ， 生物医学工程， 2000， 硕士

【摘要】 本研究合成了三种胆甾型液晶化合物，分别是胆甾醇丙烯酰氧基一缩二乙二醇碳酸酯，胆甾醇丙烯酰氧基二缩三乙二醇碳酸酯，胆甾醇丙烯酰氧基三缩四乙二醇碳酸酯。并用元素分析，红外（IR），DSC进行表征。然后分别按一定比例，与甲基含氢硅油和乙烯基硅油在氯铂酸催化剂作用下共聚制备复合膜。通过研究复合膜的表面结构形态和血液相容性，结果表明：在同一体系下，液晶含量低于30％的材料抗凝血性能和纯聚有机硅氧烷相近，液晶含量高于30％的材料抗凝血性能明显优于纯聚有机硅氧烷材料。原因是在较低的液晶含量下，液晶基团分散在复合膜中，在较高的液晶含量下，液晶化合物在材料表面形成连续相，并且有类似生物体内物质的微观有序性和生物膜的流动性的特点。在相同的液晶含量下比较，聚有机硅氧烷/胆甾醇丙烯酰氧基三缩四乙二醇碳酸酯具有最好的血液相容性。更多还原

【Abstract】 In this paper, three kinds of cholesteric liquid crystal compounds, Cholesteryl Acryloyl Oxyldiethylene Glycol Carbonate, Cholesteryl Acryloyl Oxyltriethylene Glycol Carbonate, Cholesteryl Acryloyl Oxyltetraethylene Glycol Carbonate, were synthesized and characterized by Element Analysis, Infrared Spectroscopy and Differential Scanning Calorimetry. They were copolymerized with methyl silicone oil containing hydrogen and vinyl silicone oil in certain contents to form composite membranes. After investigating the surface morphology and blood compatibility of the membranes, I got the results: in the system of same liquid crystal compound, the blood compatibility of the materials whose liquid crystal contents were lower than 30% was close with that of pure polysiloxane; otherwise the blood compatibility of the materials whose liquid crystal contents were over 30% significantly exceeded that of pure polysiloxane. The reason was : when the liquid crystal contents were low, the liquid crystal groups dispersed in the composite membranes; when the liquid crystal contents were high enough, the liquid crystal compound formed continuous phase in the surface of the materials and exhibited the characteristics of microscopic order and fluidity similar with the compounds in lives. When the liquid crystal contents were same, the blood compatibility of the membrane that were made with Cholesteryl Acryloyl Oxyltetraethylene Glycol Carbonate ranked first.更多还原