【摘要】 此文报道2例抗精神病药物所致高催乳素血症（hyperprolactinemia,HPRL）患者的中医药治疗经验。2例患者均为青年女性（29岁和18岁），分别因服用奥氮平联合艾司西酞普兰及利培酮而致催乳素水平（prolactin,PRL）显著升高（3129.76 mIU/L和1523.23 mIU/L），临床表现为月经紊乱及闭经。2例患者中医辨证均属肝郁脾肾亏虚证，均采用“疏肝解郁-健脾益气-调畅气机”的核心治法，通过调节肾-天癸-冲任轴功能，药物性HPRL得到显著改善。上述结果提示针对抗精神病药所致HPRL，中医从肝脾肾三脏论治，结合“血水同治”等经方运用策略，可有效降低PRL水平并恢复月经周期。更多还原

【Abstract】 This article reported the experience of traditional Chinese medicine treatment(TCM) in two patients with hyperprolactinemia(HPRL) induced by antipsychotic drugs. Both two patients were young females aged 29 and 18 years old respectively. Their serum prolactin(PRL) levels were markedly elevated to 3129.76 mIU/L and 1523.23 mIU/L after taking olanzapine combined with escitalopram and risperidone separately, with clinical manifestations of menstrual disorder and amenorrhea. Both patients were differentiated as syndrome of liver depression combined with spleen-kidney deficiency in TCM. The core therapeutic principles of soothing the liver and relieving stagnation, invigorating the spleen and replenishing qi, as well as regulating qi movement were adopted. By regulating the function of kidney-tiangui-chongren axis, drug-induced HPRL was significantly improved. The above results suggested that for antipsychotic-induced HPRL, TCM treatment based on regulating the liver, spleen and kidney combined with the application strategy of classical prescriptions such as simultaneous regulation of blood and fluid could effectively reduce serum PRL levels and restore menstrual cycles.更多还原