【摘要】 随着全球范围内的人口老龄化，衰老和伴随衰老的疾病给个人、家庭和社会都带来了巨大压力。传统中医学认为，衰老是随着年龄增长，机体各脏腑、组织、器官功能全面降低的过程。近年的研究显示，老年人的焦虑、抑郁状态可能会加速衰老进程。从中、西医2个角度探究焦虑、抑郁加速衰老的机制，发现中医学认为其关键发病机制在于肝失疏泄，导致气滞、瘀血、痰浊等，加速衰老；现代医学则认为其与慢性炎症、线粒体功能障碍、基因组不稳定、营养感应失调等都有关联。文章指明，未来的研究可以深入探索精神状态与衰老之间的关系，寻找更有效的干预和预防衰老策略。更多还原

【Abstract】 With the global aging population trend, aging and age-related diseases have placed significant pressure on individuals, families, and society. According to traditional Chinese medicine(TCM), aging is a process in which the functions of the internal or??gans, tissues and organs of the body decrease comprehensively with age. Recent studies have shown that anxiety and depression in the elderly may accelerate the aging process. This study explored the mechanisms by which anxiety and depression accelerate aging from the perspectives of TCM and Western medicine. It is found that in TCM, the key pathogenesis is liver failure in coursing and dis??charge, leading to qi stagnation, blood stasis, and phlegm turbidity, which accelerate aging. Modern medicine holds that it is related to chronic inflammation, mitochondrial dysfunction, genomic instability, and dysregulated nutrient sensing. This paper indicated that fu??ture research can further explore the relationship between mental state and aging, and seek more effective strategies for the interven??tion and prevention of aging.更多还原