【摘要】 目的 系统评估急性及长期运动干预对普拉德-威利综合征(PWS)儿童体质健康的影响。方法 遵循非随机干预研究的系统综述和Meta分析报告规范，通过检索PubMed、Web of Science、EBSCO等数据库，收集1987至2023年发表的关于运动干预PWS儿童体质健康影响的文献。纳入的文献主要为非随机对照试验，研究对象为PWS儿童，干预措施为急性或长期运动训练，结局指标包括心肺功能、肌肉力量、体成分、代谢指标及炎症反应等。对纳入的研究进行偏倚风险评估，并汇总分析运动干预的效果。结果 共纳入19篇研究，急性运动干预研究显示PWS儿童的心肺功能和肌肉力量均显著低于正常儿童或肥胖对照组，但其代谢反应与对照组相似。长期运动干预结果显示，PWS儿童的体重指数显著下降，肌肉质量增加，心肺功能和身体协调性均显著改善，且长期运动调节部分炎症标志物如白细胞介素-8的水平。此外，部分研究表明运动干预提升了PWS儿童的生活质量。结论 运动干预对PWS儿童的体质健康具有多方面的积极影响，尤其在控制体重、提高肌肉力量、改善心肺功能及调节炎症反应方面具有重要作用。结合激素治疗和营养干预，运动干预可为PWS儿童的健康管理提供有效的康复方案，未来应进一步优化运动处方，探索长期干预的效果和机制。更多还原

【Abstract】 Objective To systematically evaluate the effects of acute and long-term exercise interventions on the physical health of children with Prader-Willi syndrome(PWS).Methods A systematic review was conducted following the preferred reporting items for systematic reviews and meta-analyses of non-randomized studies of interventions guidelines.Relevant studies from 1987 to 2023 were retrieved from PubMed, Web of Science, and EBSCO databases.Eligible studies were primarily non-randomized controlled trials focusing on acute or long-term exercise interventions in the children with PWS.Outcome measures included cardiorespiratory function, muscle strength, body composition, metabolism, and inflammation.Results A total of 19 studies were included.Studies of acute exercise showed that the children with PWS had lower cardiorespiratory function and muscle strength than normal or obese children, but similar metabolic responses.Long-term exercise interventions resulted in significant body mass index reduction, increased muscle mass, improved cardiorespiratory function, and regulation of inflammation markers such as interleukin-8.In addition, exercise improved the quality of life in the children with PWS.Conclusions Exercise interventions positively impact the health of children with PWS by reducing the body mass index, increasing the muscle strength, improving the cardiorespiratory function, and regulating inflammation.Exercise intervention combined with hormone therapy and nutritional intervention can serve as an effective rehabilitation regimen for the health management of children with PWS.Future research should explore optimal exercise prescriptions and long-term effects and mechanisms.更多还原