【摘要】 本文报告1例43岁有肝癌家族史的慢性乙型肝炎合并代偿期肝硬化女性患者，经规范抗病毒与抗纤维化治疗，4年后进展为肝细胞癌。患者经手术切除肿瘤后恢复良好，术后持续中西医结合治疗，随访未见复发。通过该病例，结合国内外最新指南与临床实践，重点探讨慢性乙型肝炎相关肝硬化患者肝癌的二级预防与三级预防策略，强调全程化管理在降低肝癌发生与复发风险中的重要意义。更多还原

【Abstract】 We report a case of a 43-year-old female patient with a family history of hepatocellular carcinoma(HCC), who was diagnosed with chronic hepatitis B(CHB) complicated by compensated cirrhosis. Despite standard antiviral and antifibrotic therapies, the patient developed HCC four years later. She achieved an uneventful recovery after surgical tumor resection and received continuous integrated traditional Chinese and Western medicine treatment postoperatively, with no recurrence detected during regular follow-up. Based on this case, combined with the latest domestic and international guidelines and clinical practice, we focus on exploring the strategies for secondary and tertiary prevention of HCC in patients with CHB-related cirrhosis, and emphasize the vital significance of whole-course management in reducing the risks of HCC occurrence and recurrence.更多还原