【摘要】 猪繁殖与呼吸综合征（PRRS）是严重危害养猪业健康发展的主要疾病之一。针对该病，多数猪场依赖疫苗免疫和抗生素辅助治疗，但难以阻断猪繁殖与呼吸综合征病毒（PRRSV）在猪场的循环感染，猪体内病毒清除缓慢、净化困难。2024年2月，笔者针对某母猪存栏2 400头、类PRRSV NADC30毒株阳性不稳定的种猪场，采用《科赛安4招8步PRRSV净化方案》，于饲料中定期添加科赛安1号（天然产物复方制剂），结合病原和抗体监测、合理淘汰、强化生物安全、调整生产管理等综合防控方法进行PRRS防控和净化。结果显示，在方案实施2个月后，猪群实现了PRRSV核酸检测阴性；7个月后，基础母猪群PRRSV N蛋白抗体平均S/P值从1.09降至0.29，抗体阳性率从96.0%降至33.3%;4个月后引入497头PRRSV核酸和N蛋白抗体双阴性后备种猪，入群9个月一直维持PRRSV核酸和N蛋白抗体双阴性。与2023年相比，2024年该猪场各项生产指标得到了明显改善，年母猪流产数减少228窝（月均19窝），年保育猪淘汰率和死亡率分别降低10.3%和4.5%，后备种猪利用率提高16.9%。该案例证明，《科赛安4招8步PRRSV净化方案》可以促进PRRSV阳性不稳定猪群更快实现病情稳定和病毒清除，促进N蛋白抗体转阴，显著改善PRRSV阳性不稳定猪场的生产成绩，为规模猪场PRRS的防控和净化提供了参考。更多还原

【Abstract】 Porcine reproductive and respiratory syndrome(PRRS) is one of the major diseases that seriously threaten the sustainable development of the swine industry.Most pig farms rely on vaccination and antibiotic-assisted therapy to control the disease; however, it remains difficult to block the persistent circulation of porcine reproductive and respiratory syndrome virus(PRRSV) within herds, as viral clearance is slow and eradication challenging.In February 2024, we applied the “Coscian Four Strategies and Eight Steps PRRSV Eradication Program” to a breeding farm with 2 400 sows that was unstable and positive for an NADC30-like PRRSV strain.The program involved regular inclusion of Coscian No.1(a natural compound formulation) in feed, combined with pathogen and antibody monitoring, rational culling, enhanced biosecurity, and optimized management practices for integrated PRRS prevention and eradication.The results showed that after two months of implementation, all pigs tested negative for PRRSV nucleic acid.After seven months, the mean S/P ratio of PRRSV N-protein antibodies in the base sow herd decreased from 1.09 to 0.29, and the antibody-positive rate dropped from 96.0% to 33.3%.Four months later, 497 PRRSV double-negative(nucleic acid and N-protein antibody negative) replacement gilts were introduced, and the herd remained double-negative for nine consecutive months.Compared with 2023, all production indices improved significantly in 2024: the annual number of sow abortions decreased by 228 litters(an average of 19 per month), the culling and mortality rates of nursery pigs decreased by 10.3% and 4.5%, respectively, and the utilization rate of replacement gilts increased by 16.9%.This case demonstrates that the “Coscian Four Strategies and Eight Steps PRRSV Purification Program” can promote rapid stabilization and virus clearance in PRRSV-positive unstable herds, facilitate seroconversion of N-protein antibodies to negative, and significantly improve production performance.The results provide valuable reference for PRRS prevention and eradication in large-scale pig farms.更多还原