【摘要】 目的 探讨主动脉夹层（aortic dissection,AD）发生中的关键分子机制及研究进展，为AD的早期诊断与治疗提供新思路。方法 检索近年国内外相关研究文献并进行综述。结果 血管衰老是AD发生的重要病理基础，基因异常（如基因33/Mig6、CEBPB、IGFBP-3）及信号通路（Notch、铁死亡）失调在AD发生过程中具有重要作用。结论 AD的发生与血管衰老密切相关，靶向调控衰老相关基因或通路可能成为AD防治的新策略，未来需进一步开展临床转化研究验证其安全性与有效性。更多还原

【Abstract】 Objective To investigate the pivotal role and key molecular mechanisms of aortic dissection(AD)pathogenesis, providing novel perspectives for early diagnosis and treatment. Methods The relevant literature on domestic and foreign research in recent years was summarized. Results Vascular aging constitutes a fundamental pathological basis for AD, genic abnormalities(e.g., Gene 33, CEBPB, IGFBP-3) and signal pathway dysregulation(e.g.,Notch, ferroptosis) are important to genesis of AD. Conclusion AD pathogenesis is intimately linked to vascular aging.Targeting aging-associated genes or pathways may emerge as innovative strategies for AD prevention and management.Further clinical translational research is warranted to establish the safety and therapeutic efficacy.更多还原