【摘要】 目的 探讨预后营养指数（prognostic nutritional index,PNI）对静脉血栓栓塞症（venous thromboembolism,VTE）患者2年内死亡风险的预测价值。方法 回顾性收集2020年1月至2024年6月期间四川大学华西医院血管外科收治的接受3或6个月抗凝治疗的260例VTE患者的临床资料。结果 本研究根据患者出院后2年内是否死亡将患者分为死亡组（n=26）与非死亡组（n=234）。与非死亡组相比，死亡组中老年、合并营养风险、VTE复发以及PNI≤36.8的患者比例更高（P<0.05）。多因素Cox比例风险回归分析结果显示，PNI≤36.8[RR=8.579,P<0.001]、VTE复发[RR=2.648,P=0.019]、老年[RR=3.931,P=0.001]、合并高血压[RR=2.783,P=0.038]是VTE患者死亡的风险因素。结论 PNI与VTE患者死亡风险呈负相关关系，这对临床工作者早期识别高死亡风险的VTE患者具有一定指导意义。更多还原

【Abstract】 Objective This study aims to evaluate the prognostic nutritional index(PNI) as a predictor of 2-year mortality risk in patients with venous thromboembolism(VTE). Methods We conducted a retrospective analysis of clinical data from VTE patients admitted to the Department of Vascular Surgery at West China Hospital of Sichuan University between January 2020 and June 2024. Patients received either 3 or 6 months anticoagulant therapy. Results A total of 260 VTE patients were included, categorized into mortality group(n=26) and non-mortality group(n=234) based on whether live or dead in 2 years after discharge. Compare to non-mortality group, the mortality group had a higher prevalence of old-age, nutritional risk and VTE recurrence, and lower PNI level(P<0.05). Multivariable Cox proportional hazards regression analysis identified PNI<36.8 [RR=8.579, P<0.001], VTE recurrence [RR=2.648, P=0.019], old-age[RR=3.931, P=0.001], and combined hypertension [RR=2.783, P=0.038] as independent mortality risk factors in VTE patients. Conclusions The PNI is significantly negatively correlated with mortality risk in VTE patients. It serves as a valuable tool for clinicians to identify VTE patients at high risk of death early in their treatment.更多还原