【摘要】 目的：分析血管内皮生长因子（VEGF）、凋亡抑制蛋白（IAP）Livin、神经上皮干细胞蛋白（Nestin）在乳腺癌组织中的表达及与临床病理特征的关系。方法：回顾性分析2022年1月至2024年1月该院收治的90例乳腺癌患者的临床资料，比较VEGF、IAP Livin、Nestin在乳腺癌组织与癌旁组织中的阳性表达率及在不同病理特征乳腺癌患者中的阳性表达率。结果：VEGF、IAP Livin、Nestin在乳腺癌组织中的阳性表达率均高于癌旁组织，差异有统计学意义（P<0.05）；分化程度为低分化、组织学分级为Ⅲ级、有淋巴结转移、临床分期为Ⅲ期乳腺癌患者乳腺癌组织VEGF、IAP Livin、Nestin阳性表达率均高于其他类型患者，差异有统计学意义（P<0.05）。结论：VEGF、IAP Livin、Nestin在乳腺癌组织中的阳性表达率均高于癌旁组织，且分化程度为低分化、组织学分级为Ⅲ级、有淋巴结转移、临床分期为Ⅲ期乳腺癌患者VEGF、IAP Livin、Nestin阳性表达率均高于其他类型患者。更多还原

【Abstract】 Objective: To analyze expressions of vascular endothelial growth factor(VEGF), inhibitor of apoptosis protein(IAP) Livin and neuroepithelial stem cell protein(Nestin) in breast cancer tissues and their relationship with clinicopathological features. Methods: The clinical data of 90 patients with breast cancer admitted to this hospital from January 2022 to January 2024 were retrospectively analyzed. The positive expression rates of VEGF, IAP Livin and Nestin in the breast cancer tissues and the adjacent tissues and the positive expression rates in the breast cancer patients with different pathological characteristics were compared. Results: The positive expression rates of VEGF, IAP Livin and Nestin in the breast cancer tissues were higher than those in the adjacent tissues, and the differences were statistically significant(P<0.05). The positive expression rates of VEGF, IAP Livin and Nestin in breast cancer tissues of patients with poorly differentiated, histological grade Ⅲ, lymph node metastasis and clinical stage Ⅲ breast cancer were higher than those in other types of patients, and the differences were statistically significant(P<0.05). Conclusions: The positive expression rates of VEGF, IAP Livin and Nestin in the breast cancer tissues are higher than those in the adjacent tissues. The positive expression rates of VEGF, IAP Livin and Nestin were all relatively high in breast cancer tissues of patients with poorly differentiated, histological grade III, lymph node metastasis and clinical stage Ⅲ breast cancer are higher than those in other types of patients.更多还原