【摘要】 目的 探讨2008—2021年连云港市宫颈癌发病趋势及年龄变化情况。方法 收集连云港市所有肿瘤登记处的宫颈癌发病资料，进行整理与质量控制。计算2008—2021年各年度宫颈癌发病率、中国人口标化发病率(中标率)和分年龄组发病率，并使用Joinpoint回归模型计算发病率、中标发病率和分年龄组发病率的平均年度变化百分比(AAPC);计算平均发病年龄及中标平均发病年龄，采用线性回归模型分析平均发病年龄和中标平均发病年龄的变化趋势；计算并比较2008和2021年中标发病构成比及变化。结果 2021年连云港市宫颈癌的发病率(14.57/10万)较2008年(7.05/10万)增长2.07倍。2008—2021年连云港市宫颈癌的发病率(AAPC=5.62%,P<0.001)和中标发病率(AAPC=4.08%,P<0.001)均呈增长趋势，农村地区中标发病率(AAPC=4.84%,P<0.001)呈增长趋势，而城市地区无明显变化(P>0.05)。各年龄组发病率趋势中，30～39岁、50～59岁、60～69岁和70～79岁4个年龄组呈现明显增长趋势；分年龄组中50～59岁组发病率最高；宫颈癌的平均发病年龄由2008年的51.87岁增加至2021年的54.64岁(β=0.329,P<0.001),标化后平均发病年龄变化趋势无统计学意义(P>0.05)。与2008年相比，2021年45～49岁年龄组总构成比明显升高，由34.13%升至42.75%。结论 2008—2021年连云港市宫颈癌的发病水平呈现上升趋势，农村地区增长速度高于城市地区，50～59岁年龄组女性为高发群体。针对宫颈癌的流行现状，建议采取多种预防措施对重点地区和重点人群进行综合防控。更多还原

【Abstract】 Objective To investigate the incidence trend and age distribution changes of cervical cancer in Lianyungang City from 2008 to 2021. Methods Cervical cancer incidence data from all cancer registries in Lianyungang City were collected, organized, and quality-controlled. The annual incidence rate of cervical cancer, age-standardized incidence rate(ASIRC) of Chinese standard population, and age-specific incidence rates from 2008 to 2021 were calculated. The average annual percentage change(AAPC) in incidence rate, ASIRC, and age-specific incidence rates were analyzed using the Joinpoint regression model. The average age at diagnosis and the age-standardized average age at diagnosis were calculated, and linear regression models were used to analyze trends in these average ages. The ASIRC composition ratios for 2008 and 2021 were compared to assess changes. Results The incidence rate of cervical cancer in Lianyungang City increased 2.07-fold from 7.05/100 000 in 2008 to 14.57/100 000 in 2021. From 2008 to 2021, both the crude incidence rate(AAPC=5.62%, P<0.001) and ASIRC(AAPC=4.08%, P<0.001) of cervical cancer showed an increasing trend. In rural areas, ASIRC exhibited a significant growth trend(AAPC=4.84%, P<0.001), while no significant change was observed in urban areas(P>0.05). Among age-specific incidence trends, four age groups—30-39, 50-59, 60-69, and 70-79 years—showed significant increases. The 50-59 age group had the highest incidence rate and the largest increase in ASIRC composition ratio. The average age at diagnosis increased from 51.87 years in 2008 to 54.64 years in 2021(β=0.329, P<0.001), but after standardization, the trend in average age at diagnosis was not statistically significant(P>0.05). Compared to the data of 2008, the age group of 45-49 showed significant increase of composition ratio, from 34.13% to 42.75%. Conclusions From 2008 to 2021, the incidence of cervical cancer in Lianyungang City showed an upward trend, with rural areas experiencing a faster growth rate than urban areas. Women aged 50-59 were identified as the high-risk group. In response to the current epidemiological situation of cervical cancer, it is recommended to implement various preventive measures for comprehensive prevention and control in key areas and among key populations.更多还原