【摘要】 [目的]采用荟萃分析评价间充质干细胞源性细胞外囊泡（mesenchymal stem cell-derived extracellular vesicles, MSCEVs）在颅颌骨缺损修复中的疗效。[方法]检索PubMed、Embase、Cochrane、Web of Science、中国知网、万方、维普和中国生物医学文献数据库建库至2025年5月，符合标准的文献资料，应用SYRCLE工具评估偏倚风险，使用Revman 5.4.1软件和Getdata Graph Digitizer软件提取数据并进行分析。[结果]共12篇文献符合纳入标准，均为动物实验。荟萃分析显示，MSC-EVs组在骨体积与总体积比（SMD=3.97, 95%CI 2.50～5.43, P<0.001）、骨密度（SMD=5.89, 95%CI 3.50～8.29, P<0.001）、骨小梁数量（SMD=3.01, 95%CI 0.42～5.60, P=0.02）、骨小梁分离度（SMD=-3.48, 95%CI-5.84～-1.12, P=0.004）、血管容积（SMD=4.69, 95%CI3.03～6.36, P<0.001）均显著优于对照组，此外，未预处理的MSC-EVs组与预处理的MSC-EVs组之间的差异均无统计学意义（P>0.05）。[结论] MSC-EVs疗法在加速颅颌骨缺损愈合方面具有显著疗效，未预处理的MSC-EVs组与预处理的MSC-EVs组之间无明显差异。更多还原

【Abstract】 [Objective] To evaluate the efficacy of mesenchymal stem cell-derived extracellular vesicles(MSC-EVs) in the repair of craniomaxillofacial bone defects. [Methods] The literature data that met the criteria were retrieved in PubMed, Embase, Cochrane, Web of Science, China National Knowledge Infrastructure(CNKI), Wanfang, VIP and the Chinese Biomedical Literature Database from the establishment until May 2025. The SYRCLE tool was applied to assess the risk of bias. Data were extracted and analyzed using Revman 5.4.1 software and Getdata Graph Digitizer software. [Results] A total of 12 literature met the inclusion criteria, and all of them involved animal experiment. As results of the meta-analysis, the MSC-EVs group proved significantly superior to the control group in terms of the ratio of bone volume to total volume(SMD=3.97, 95%CI 2.50～5.43, P<0.00001), bone mineral density(SMD=5.89, 95%CI 3.50～8.29, P<0.00001), trabecular bone number(SMD=3.01, 95%CI 0.42～5.60, P=0.02), trabecular separation(SMD=-3.48, 95%CI-5.84～-1.12, P=0.004) and vessel volume(SMD=4.69, 95%CI 3.03～6.36, P<0.00001).However, there was no significant difference between the unpretreated MSC-EVs group and the pretreated MSC-EVs group in abovesaid parameters. [Conclusion] MSC-EVs therapy has a significant effect in accelerating the healing of craniomaxillofacial bone defects. There was no significant difference between the unpretreated MSC-EVs group and the pretreated MSC-EVs group.更多还原