【摘要】 目的 了解绍兴市多家医院临床分离的耐甲氧西林金黄色葡萄球菌（MRSA）的耐药现状及特征。方法通过病原菌采集标本检测和分离培养的方法，对绍兴市13家医院临床分离到的金黄色葡萄球菌检测资料进行统计分析。结果 剔除重复菌株后，共分离到金黄色葡萄球菌3 401株，其中MRSA1 117株，MRSA检出率为32.8%。MRSA菌株主要来源于重症监护病房、普通病房及门诊。药敏结果显示，MRSA对万古霉素、替加环素和头孢罗膦比较敏感；对红霉素的耐药率高达64.3%。绍兴市不同医院分离的MRSA对多数抗菌药物的耐药率差异具有统计学意义（P<0.05）。结论 绍兴市临床分离的MRSA耐药形势严峻，且不同医院间耐药率存在差异。需持续加强区域性耐药监测，规范抗菌药物使用，以遏制耐药菌的发展。更多还原

【Abstract】 Objective To understand the current status and characteristics of methicillin-resistant Staphylococcus aureus(MRSA) resistance in clinical isolates from some hospitals in Shaoxing area. Methods Through pathogen collection, specimen testing, and isolation and cultivation, the data of Staphylococcus aureus clinically isolated from 13 hospitals in Shaoxing area was analyzed statistically. Results After removing duplicate strains, a total of 3 401 strains of Staphylococcus aureus were isolated, including 1 117 strains of MRSA, with a MRSA detection rate of 32.8%. MRSA strains were mainly isolated from intensive care units(ICUs), general wards, and outpatient clinics. The drug sensitivity test results showed that MRSA was more sensitive to vancomycin, tigecycline, and cefuroxime. The resistance rate to erythromycin was as high as 64.3%. The difference in resistance rates of MRSA isolated from different hospitals in Shaoxing area to most antibiotics was statistically significant(P<0.05). Conclusion The drug resistance situation of MRSA isolated clinically in Shaoxing area is severe, and there are differences in drug resistance rates among different hospitals. We need to continuously strengthen regional drug resistance monitoring and standardize the use of antibiotics to curb the development of drug-resistant bacteria.更多还原